BIBR 1087 SE (Synonyms: Desethyl Dabigatran Etexilate)

Name: BIBR 1087 SE
Brand: MedChemExpress
SKU: HY-W004360
Rating: 4.5 (1 reviews)

Cat. No.: HY-W004360 Purity: 96.57%: FAQs
Data Sheet SDS COA Handling Instructions

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BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.

For research use only. We do not sell to patients.

BIBR 1087 SE Chemical Structure

CAS No. : 212321-78-3

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 211	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 211	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 256	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 512	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of BIBR 1087 SE:

Dabigatran etexilate In-stock

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Description

BIBR 1087 SE is an intermediate metabolite of dabigatran etexilate.

Molecular Weight

599.68

Formula

C₃₂H₃₇N₇O₅

CAS No.

212321-78-3

Appearance

Solid

Color

White to yellow

SMILES

N=C(C1=CC=C(C=C1)NCC2=NC3=CC(C(N(CCC(O)=O)C4=NC=CC=C4)=O)=CC=C3N2C)NC(OCCCCCC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (416.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6676 mL	8.3378 mL	16.6756 mL
5 mM	0.3335 mL	1.6676 mL	3.3351 mL
10 mM	0.1668 mL	0.8338 mL	1.6676 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.47 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 96.57%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (244 KB) HNMR (285 KB) LCMS (272 KB)

Handling Instructions (2659 KB)

References

[1]. Stangier J, et al. Pharmacokinetics and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor, are not affected by moderate hepatic impairment. J Clin Pharmacol. 2008 Dec;48(12):1411-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6676 mL	8.3378 mL	16.6756 mL	41.6889 mL
	5 mM	0.3335 mL	1.6676 mL	3.3351 mL	8.3378 mL
	10 mM	0.1668 mL	0.8338 mL	1.6676 mL	4.1689 mL
	15 mM	0.1112 mL	0.5559 mL	1.1117 mL	2.7793 mL
	20 mM	0.0834 mL	0.4169 mL	0.8338 mL	2.0844 mL
	25 mM	0.0667 mL	0.3335 mL	0.6670 mL	1.6676 mL
	30 mM	0.0556 mL	0.2779 mL	0.5559 mL	1.3896 mL
	40 mM	0.0417 mL	0.2084 mL	0.4169 mL	1.0422 mL
	50 mM	0.0334 mL	0.1668 mL	0.3335 mL	0.8338 mL
	60 mM	0.0278 mL	0.1390 mL	0.2779 mL	0.6948 mL
	80 mM	0.0208 mL	0.1042 mL	0.2084 mL	0.5211 mL
	100 mM	0.0167 mL	0.0834 mL	0.1668 mL	0.4169 mL

BIBR 1087 SE Related Classifications

Metabolic Disease Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BIBR 1087 SE212321-78-3Desethyl Dabigatran EtexilateOthersInhibitorinhibitorinhibit

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BIBR 1087 SE (Synonyms: Desethyl Dabigatran Etexilate)

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Complete Stock Solution Preparation Table

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