2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. cPrPMEDAP

cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin.

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cPrPMEDAP Chemical Structure

cPrPMEDAP Chemical Structure

CAS No. : 182798-83-0

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Based on 1 publication(s) in Google Scholar

cPrPMEDAP Related Antibodies

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Description

cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin[1][2].

In Vitro

cPrPMEDAP shows antiproliferative activity in SiHa cells with an EC50 of 290 nM (SiHa cells: HPV-transformed cervical carcinoma cell lines)[1].
PMEG forms an active phosphorylated metabolite, PMEG diphosphate (PMEG-DP), in cells, which inhibits the growth of various transformed cell lines due to potent inhibition of the nuclear DNA polymerases α, δ and ɛ, resulting in inhibition of DNA synthesis and/or DNA repair. In animal models, PMEG has antiproliferative effects; the utility of PMEG as an antiproliferative agent is limited by its poor cellular permeability and toxicity. cPrPMEDAP has similar antiproliferative effects in vitro and reduced toxicity in vivo but, like PMEG, is negatively charged at physiologic pH and has poor permeability into the skin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cPrPMEDAP Related Antibodies
Molecular Weight

328.26

Formula

C11H17N6O4P
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC(NC2CC2)=C3N=CN(CCOCP(O)(O)=O)C3=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (30.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0464 mL 15.2318 mL 30.4637 mL
5 mM 0.6093 mL 3.0464 mL 6.0927 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0464 mL 15.2318 mL 30.4637 mL 76.1591 mL
5 mM 0.6093 mL 3.0464 mL 6.0927 mL 15.2318 mL
10 mM 0.3046 mL 1.5232 mL 3.0464 mL 7.6159 mL
15 mM 0.2031 mL 1.0155 mL 2.0309 mL 5.0773 mL
20 mM 0.1523 mL 0.7616 mL 1.5232 mL 3.8080 mL
25 mM 0.1219 mL 0.6093 mL 1.2185 mL 3.0464 mL
30 mM 0.1015 mL 0.5077 mL 1.0155 mL 2.5386 mL
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cPrPMEDAP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cPrPMEDAP182798-83-0Drug Metaboliteprodrugnucleotide analogantiproliferativeSiHa cellsInhibitorinhibitorinhibit

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