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Results for "

iron chelator

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

2

Biochemical Assay Reagents

2

Natural
Products

1

Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114837
    HBED

    		Ferroptosis Cancer
    HBED is a potent iron chelator. HBED can be used to study transfusional iron overload .
    HBED
  • HY-17359
    Deferasirox
    5+ Cited Publications

    ICL 670

    		 Bacterial Ferroptosis Cancer
    Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
    Deferasirox
  • HY-131060
    CN128 hydrochloride

    CN328

    		 Others Others
    CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia .
    CN128 hydrochloride
  • HY-108260
    Deferitrin

    GT-56-252

    		 Others Cardiovascular Disease
    Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major .
    Deferitrin
  • HY-126164
    LK 614

    		Biochemical Assay Reagents Others
    LK 614 is a membrane permeable iron chelator that can be used to study the protective effects against L-Histidine (HY-N0832)-induced cell damage .
    LK 614
  • HY-124712
    Divin

    		Bacterial Infection
    Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm .
    Divin
  • HY-108194
    CGP 46700

    		Biochemical Assay Reagents Others
    CGP 46700 (Compound 49) is an orally active iron chelator, that exhibits high affinity for iron, removes iron from ferritin and human serum transferrin. CGP 46700 promotes iron excretion in a mouse iron overload model .
    CGP 46700
  • HY-101672
    Deferitazole

    FBS 0701

    		 Ferroptosis Parasite Infection
    Deferitazole (FBS 0701) is an orally active iron chelator. Deferitazole shows antimalarial activity and Can be used for study of malaria .
    Deferitazole
  • HY-W686216
    VK-28

    		Ferroptosis Neurological Disease
    VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases .
    VK-28
  • HY-100329
    CGP 65015

    		Ferroptosis Others
    CGP 65015 is an oral iron chelator, which can mobilize iron deposits.
    CGP 65015
  • HY-124452
    Nocardamine

    Desferrioxamine E; Nocardamin

    		 Bacterial Others
    Nocardamine (Deferrioxamine E)is an iron carrier/Iron chelator with antimicrobial activity .
    Nocardamine
  • HY-16912
    SP-420

    		Others Others
    SP-420 is a tridentate iron chelator belonging to the class of iron chelators, with oral activity. It is a derivative of desferrithiocin but has higher iron clearance efficiency and minimized renal toxicity compared to desferrithiocin, with an ICE (Iron Clearance Efficiency) value of 26.7. SP-420 can be used in research related to β-thalassemia .
    SP-420
  • HY-18973
    Dp44mT
    4 Publications Verification

    		 Apoptosis Ferroptosis Cancer
    Dp44mT is an iron chelator with selective anticancer activity.
    Dp44mT
  • HY-131036
    MAO-IN-M30 dihydrochloride

    		Monoamine Oxidase Neurological Disease
    MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    MAO-IN-M30 dihydrochloride
  • HY-156776
    HAPSBC

    		Others Others
    HAPSBC is an S-benzyl iron chelator that mobilizes intracellular 59Fe distribution .
    HAPSBC
  • HY-160078
    Deferiprone O-β-D-glucuronide

    		Others Metabolic Disease
    Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron burden in patients with β-thalassemia .
    Deferiprone O-β-D-glucuronide
  • HY-17359R
    Deferasirox (Standard)

    ICL 670 (Standard)

    		 Bacterial Ferroptosis Cancer
    Deferasirox (Standard) is the analytical standard of Deferasirox. This product is intended for research and analytical applications. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
    Deferasirox (Standard)
  • HY-W339484
    1-Ethyl-2-methyl-3-hydroxypyrid-4-one

    		Others Others
    1-Ethyl-2-methyl-3-hydroxypyrid-4-one is an α-ketohydroxypyridinium iron chelator that increases iron excretion in iron-overloaded rabbits after oral or parenteral administration and is highly specific for iron, with no specific activity for copper, zinc, calcium, and magnesium.
    1-Ethyl-2-methyl-3-hydroxypyrid-4-one
  • HY-W035520
    HBED dihydrochloride

    		Biochemical Assay Reagents Others
    HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy .
    HBED dihydrochloride
  • HY-120475
    PBT434

    ATH434

    		 α-synuclein Neurological Disease
    PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .
    PBT434
  • HY-142072
    Albomycin

    		Antibiotic DNA/RNA Synthesis Bacterial Infection
    Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer .
    Albomycin
  • HY-120475A
    PBT434 mesylate

    ATH434 mesylate

    		 α-synuclein Neurological Disease
    PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .
    PBT434 mesylate
  • HY-169298
    Ferroptosis-IN-15

    		Ferroptosis Cancer
    Ferroptosis-IN-15 (compound 12) is a potent inhibitor of ferroptosis, with the EC50s of 0.76 and 0.67 μM in A375 cells and 786-O cells, respectively.Ferroptosis-IN-15 is a potential iron chelator and radical trapping antioxidant .
    Ferroptosis-IN-15
  • HY-N0928
    Mimosine

    		Apoptosis Inflammation/Immunology Cancer
    Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.
    Mimosine
  • HY-B0988
    Deferoxamine mesylate
    Maximum Cited Publications
    218 Publications Verification

    Desferrioxamine B mesylate; DFOM

    		 Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Apoptosis Akt Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
    Deferoxamine mesylate
  • HY-B1625
    Deferoxamine
    Maximum Cited Publications
    218 Publications Verification

    Deferoxamine B; Deferriferrioxamine B; Deferrioxamine

    		 HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Apoptosis Akt Autophagy Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
    Deferoxamine
  • HY-B0988R
    Deferoxamine mesylate (Standard)

    		Autophagy HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Apoptosis Akt Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Deferoxamine (mesylate) (Standard) is the analytical standard of Deferoxamine (mesylate). This product is intended for research and analytical applications. Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
    Deferoxamine mesylate (Standard)
  • HY-B1625R
    Deferoxamine (Standard)

    		HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species Apoptosis Akt Autophagy Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Deferoxamine (Standard) is the analytical standard of Deferoxamine. This product is intended for research and analytical applications. Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
    Deferoxamine (Standard)
  • HY-N8707
    Homobutein

    		Parasite HDAC NF-κB Infection Inflammation/Immunology Cancer
    Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .
    Homobutein
  • HY-12406
    VLX600

    		Oxidative Phosphorylation Mitochondrial Metabolism Autophagy Cancer
    VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity .
    VLX600
  • HY-163879
    hMAO-B-IN-9

    		Monoamine Oxidase Reactive Oxygen Species Ferroptosis Neurological Disease
    hMAO-B-IN-9 (Compound 25c) is a non-competitive inhibitor for monoamine oxidase B (MAO-B) with an IC50 of 1.58 µM (hMAO-B). hMAO-B-IN-9 forms complex with iron ions as a chelator, and inhibits Erastin (HY-15763)-induced ferroptosis. hMAO-B-IN-9 exhibits antioxidant activity by downregulating the level of reactive oxygen species (ROS). hMAO-B-IN-9 improves cognitive function in mice, without significant toxicity (30 mg/kg). hMAO-B-IN-9 is blood-brain barrier permeable, according to the in silico prediction .
    hMAO-B-IN-9

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