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  4. HBED dihydrochloride

HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy.

For research use only. We do not sell to patients.

HBED dihydrochloride Chemical Structure

HBED dihydrochloride Chemical Structure

CAS No. : 35369-53-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 38 In-stock
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10 mM * 1 mL in DMSO USD 38 In-stock
Solid
100 mg USD 35 In-stock
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Based on 1 publication(s) in Google Scholar

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HBED dihydrochloride Related Antibodies

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Description

HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy[1].

In Vivo

HBED monohydrochloride dihydrate produces different activity under different dosing methods. HBED does not produce significant effects when administered orally at doses of 81, 162, and 324 μMol/kg. After subcutaneous administration of 162 and 324 μMol/kg, the net iron excretion is increased[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

461.34

Formula

C20H26Cl2N2O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C=CC=C1)CN(CCN(CC2=C(C=CC=C2)O)CC(O)=O)CC(O)=O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1676 mL 10.8380 mL 21.6760 mL
5 mM 0.4335 mL 2.1676 mL 4.3352 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

COA (254 KB)

Handling Instructions (2659 KB)
References
Animal Administration

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1676 mL 10.8380 mL 21.6760 mL 54.1900 mL
5 mM 0.4335 mL 2.1676 mL 4.3352 mL 10.8380 mL
10 mM 0.2168 mL 1.0838 mL 2.1676 mL 5.4190 mL
15 mM 0.1445 mL 0.7225 mL 1.4451 mL 3.6127 mL
20 mM 0.1084 mL 0.5419 mL 1.0838 mL 2.7095 mL
25 mM 0.0867 mL 0.4335 mL 0.8670 mL 2.1676 mL
30 mM 0.0723 mL 0.3613 mL 0.7225 mL 1.8063 mL
40 mM 0.0542 mL 0.2709 mL 0.5419 mL 1.3547 mL
50 mM 0.0434 mL 0.2168 mL 0.4335 mL 1.0838 mL
60 mM 0.0361 mL 0.1806 mL 0.3613 mL 0.9032 mL
80 mM 0.0271 mL 0.1355 mL 0.2709 mL 0.6774 mL
100 mM 0.0217 mL 0.1084 mL 0.2168 mL 0.5419 mL
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HBED dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HBED35369-53-0Biochemical Assay ReagentsInhibitorinhibitorinhibit

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