2. Apoptosis
  3. Ferroptosis
  4. CGP 65015

CGP 65015 is an oral iron chelator, which can mobilize iron deposits.

For research use only. We do not sell to patients.

CGP 65015 Chemical Structure

CGP 65015 Chemical Structure

CAS No. : 189564-33-8

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CGP 65015 Related Antibodies

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Description

CGP 65015 is an oral iron chelator, which can mobilize iron deposits.

In Vitro

CGP 65015 is an oral iron chelator[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CGP 65015 Related Antibodies
In Vivo

CGP65015 (150 μmol IBE/kg p.o. on d0) dramatically increases the urinary and faecal iron clearance, and still enhances iron elimination during the second post-treatment day in iron-overloaded marmosets[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

261.27

Formula

C14H15NO4
CAS No.
SMILES

O=C1C(O)=C(C(O)C2=CC=CC=C2)N(CCO)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[1]

Marmosets[1]
To approximate the iron status of thalassaemic patients in the marmosets, the animals are iron-overloaded by three i.p. injections of iron (III) hydroxide polyisomaltose at 14-d intervals (200 mg/kg twice and 100 mg/kg at the third injection). Prior to the first exposure to an iron chelator (CGP 65015), the marmosets are rested for at least 8 weeks in order to allow definite distribution of the injected iron into all storage compartments. CGP 65015 is dispersed in 40% aqueous Cremophor RH 40 for oral administration of 150 μmol IBE/kg. All dosages are expressed in terms of 'iron binding equivalents' (IBE) which take into account the stoichiometry of the chelator in the iron complex, i.e. 150 μmol IBE correspond to 150, 300 and 450 μmol of a mono-, bi- and tridentate chelator respectively. The standard dose is 150 μmol iron binding equivalents (IBE) per kg body weight. The applied volume is 5 mL/kg body weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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CGP 65015 Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 65015189564-33-8CGP65015CGP-65015FerroptosisInhibitorinhibitorinhibit

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