2. Apoptosis
  3. Apoptosis
  4. Mimosine

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity. Mimosine is a known chelator of Fe(III). Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells. Anti-cancer, antiinflammation.

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Mimosine Chemical Structure

Mimosine Chemical Structure

CAS No. : 500-44-7

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Based on 1 publication(s) in Google Scholar

Mimosine Related Antibodies

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  • Purity & Documentation

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Description

Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity[1]. Mimosine is a known chelator of Fe(III)[2]. Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells[3]. Anti-cancer, antiinflammation.

In Vitro

Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore[2].
Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena[2].
Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa[4].
Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells[4].
Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mimosine Related Antibodies
In Vivo

Mimosine (30, and 60 mg/kg) decreases sperm concentration[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR male mice (6-8 weeks)[5]
Dosage: 15, 30, or 60 mg/kg
Administration: Injected (i.p.) for 7 consecutive days
Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.
Molecular Weight

198.18

Formula

C8H10N2O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC([C@@H](N)CN1C=CC(C(O)=C1)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.23 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0459 mL 25.2296 mL 50.4592 mL
5 mM 1.0092 mL 5.0459 mL 10.0918 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

=
Concentration (final)

C2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (10.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.92%

COA (247 KB) HNMR (250 KB) LCMS (92 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.0459 mL 25.2296 mL 50.4592 mL 126.1480 mL
5 mM 1.0092 mL 5.0459 mL 10.0918 mL 25.2296 mL
10 mM 0.5046 mL 2.5230 mL 5.0459 mL 12.6148 mL
15 mM 0.3364 mL 1.6820 mL 3.3639 mL 8.4099 mL
20 mM 0.2523 mL 1.2615 mL 2.5230 mL 6.3074 mL
25 mM 0.2018 mL 1.0092 mL 2.0184 mL 5.0459 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mimosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mimosine500-44-7Apoptosisantioxidantiron-bindingchelatorFe(III)Anti-cancerantiinflammationanti-fibrosisanti-influenzaanti-virusherbicidainsecticidalInhibitorinhibitorinhibit

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