2. Anti-infection
  3. Bacterial
  4. Divin

Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm.

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Divin Chemical Structure

Divin Chemical Structure

CAS No. : 1443321-11-6

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Description

Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm[1][2][3].

Molecular Weight

372.42

Formula

C22H20N4O2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(N/N=C/C1=C2C=CC=CC2=CC=C1O)CCN3C4=CC=CC=C4N=C3C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (53.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6851 mL 13.4257 mL 26.8514 mL
5 mM 0.5370 mL 2.6851 mL 5.3703 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6851 mL 13.4257 mL 26.8514 mL 67.1285 mL
5 mM 0.5370 mL 2.6851 mL 5.3703 mL 13.4257 mL
10 mM 0.2685 mL 1.3426 mL 2.6851 mL 6.7129 mL
15 mM 0.1790 mL 0.8950 mL 1.7901 mL 4.4752 mL
20 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3564 mL
25 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6851 mL
30 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2376 mL
40 mM 0.0671 mL 0.3356 mL 0.6713 mL 1.6782 mL
50 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
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Divin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Divin1443321-11-6BacterialGram-negativeGram-positivebacteriadivisionchelatorironassemblypeptidoglycancompartmentalizatioInhibitorinhibitorinhibit

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