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Deferitrin  (Synonyms: GT-56-252)

Cat. No.: HY-108260 Purity: 99.32%
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Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major.

For research use only. We do not sell to patients.

Deferitrin Chemical Structure

Deferitrin Chemical Structure

CAS No. : 239101-33-8

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1 mg USD 130 In-stock
5 mg USD 300 In-stock
10 mg USD 465 In-stock
25 mg USD 740 In-stock
50 mg USD 1040 In-stock
100 mg USD 1450 In-stock
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Based on 1 publication(s) in Google Scholar

Deferitrin Related Antibodies

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Description

Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major[1][2].

In Vitro

The iron-clearing efficiency (ICE) of Deferitrin (GT-56-252) in a non-iron-overloaded rodent model after oral (po) administration at 300 µmol/kg is shown to be 1.1%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Deferitrin Related Antibodies
Clinical Trial
Molecular Weight

253.27

Formula

C11H11NO4S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C([C@]1(C)N=C(C2=CC=C(O)C=C2O)SC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (493.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9484 mL 19.7418 mL 39.4836 mL
5 mM 0.7897 mL 3.9484 mL 7.8967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9484 mL 19.7418 mL 39.4836 mL 98.7089 mL
5 mM 0.7897 mL 3.9484 mL 7.8967 mL 19.7418 mL
10 mM 0.3948 mL 1.9742 mL 3.9484 mL 9.8709 mL
15 mM 0.2632 mL 1.3161 mL 2.6322 mL 6.5806 mL
20 mM 0.1974 mL 0.9871 mL 1.9742 mL 4.9354 mL
25 mM 0.1579 mL 0.7897 mL 1.5793 mL 3.9484 mL
30 mM 0.1316 mL 0.6581 mL 1.3161 mL 3.2903 mL
40 mM 0.0987 mL 0.4935 mL 0.9871 mL 2.4677 mL
50 mM 0.0790 mL 0.3948 mL 0.7897 mL 1.9742 mL
60 mM 0.0658 mL 0.3290 mL 0.6581 mL 1.6451 mL
80 mM 0.0494 mL 0.2468 mL 0.4935 mL 1.2339 mL
100 mM 0.0395 mL 0.1974 mL 0.3948 mL 0.9871 mL
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Deferitrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Deferitrin239101-33-8GT-56-252Othersdesferrithiocinorallytridentironchelatorchronicoverloadtransfusionaltherapybeta-thalassemiaInhibitorinhibitorinhibit

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