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SP-420 is a tridentate iron chelator belonging to the class of iron chelators, with oral activity. It is a derivative of desferrithiocin but has higher iron clearance efficiency and minimized renal toxicity compared to desferrithiocin, with an ICE (Iron Clearance Efficiency) value of 26.7. SP-420 can be used in research related to β-thalassemia.

For research use only. We do not sell to patients.

SP-420 Chemical Structure

SP-420 Chemical Structure

CAS No. : 911714-45-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 89 In-stock
Solution
10 mM * 1 mL in DMSO USD 89 In-stock
Solid
1 mg USD 36 In-stock
5 mg USD 81 In-stock
10 mg USD 148 In-stock
25 mg USD 324 In-stock
50 mg USD 576 In-stock
100 mg USD 1035 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

SP-420 Related Antibodies

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Description

SP-420 is a tridentate iron chelator belonging to the class of iron chelators, with oral activity. It is a derivative of desferrithiocin but has higher iron clearance efficiency and minimized renal toxicity compared to desferrithiocin, with an ICE (Iron Clearance Efficiency) value of 26.7. SP-420 can be used in research related to β-thalassemia[1][2][3].

Clinical Trial
Molecular Weight

355.41

Formula

C16H21NO6S
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C([C@]1(C)N=C(C2=CC=C(OCCOCCOC)C=C2O)SC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 38 mg/mL (106.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8137 mL 14.0683 mL 28.1365 mL
5 mM 0.5627 mL 2.8137 mL 5.6273 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8137 mL 14.0683 mL 28.1365 mL 70.3413 mL
5 mM 0.5627 mL 2.8137 mL 5.6273 mL 14.0683 mL
10 mM 0.2814 mL 1.4068 mL 2.8137 mL 7.0341 mL
15 mM 0.1876 mL 0.9379 mL 1.8758 mL 4.6894 mL
20 mM 0.1407 mL 0.7034 mL 1.4068 mL 3.5171 mL
25 mM 0.1125 mL 0.5627 mL 1.1255 mL 2.8137 mL
30 mM 0.0938 mL 0.4689 mL 0.9379 mL 2.3447 mL
40 mM 0.0703 mL 0.3517 mL 0.7034 mL 1.7585 mL
50 mM 0.0563 mL 0.2814 mL 0.5627 mL 1.4068 mL
60 mM 0.0469 mL 0.2345 mL 0.4689 mL 1.1724 mL
80 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.8793 mL
100 mM 0.0281 mL 0.1407 mL 0.2814 mL 0.7034 mL
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SP-420 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP-420911714-45-9SP420SP 420OthersInhibitorinhibitorinhibit

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