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Isoforms Recommended:	mGluR2

Results for "

mGluR2

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By Targets:	Endogenous Metabolite (4) ERK (2) GABA Receptor (2) iGluR (1) mGluR (33) Src (1)
By Research Areas:	Metabolic Disease (2) Neurological Disease (32)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133555

mGluR2 antagonist 1	mGluR	Neurological Disease
mGluR2 antagonist 1 is a highly potent, orally bioavailable and selective class of *mGluR2* negative allosteric modulator (IC₅₀ of 9 nM) with excellent brain permeability .

HY-130630

mGluR2 modulator 1	mGluR	Neurological Disease
mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated *mGluR2* (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC₅₀ of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research .

HY-16766

Decoglurant RO4995819	mGluR	Neurological Disease
Decoglurant (RO4995819) is a negative allosteric modulator of *mGluR2* and *mGluR3*. Decoglurant is developed as an antidepressant .

HY-15442

Biphenylindanone A BINA	mGluR	Neurological Disease
Biphenylindanone A (BINA) is a selective human *mGluR2* (hmGluR2) potentiator for the treatment of many neurological disorders .

HY-147530

mGluR2 modulator 4	mGluR	Neurological Disease
mGluR2 modulator 4 (compound 47) is a potent *mGluR2* positive allosteric modulator with an EC₅₀ value of 0.8 μM. mGluR2 modulator 4 can be used for researching antipsychotic .

HY-147528

mGluR2 modulator 2	mGluR	Neurological Disease
mGluR2 modulator 2 (compound 2) is a potent, selective and orally bioavailable *mGluR2* positive allosteric modulator with an EC₅₀ value of 0.13 μM. mGluR2 modulator 2 can be used for researching antipsychotic .

HY-147529

mGluR2 modulator 3	mGluR	Neurological Disease
mGluR2 modulator 3 (compound 1) is a potent *mGluR2* positive allosteric modulator with an EC₅₀ value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice .

HY-168028

mGluR2 modulator 5	mGluR	Neurological Disease
mGluR2 modulator 5 (Compound 11) is an orally active, selective *mGluR2* negative allosteric modulator with an IC₅₀ of 8.9 nM. Pharmacokinetic studies in rats show that mGluR2 modulator 5 can effectively cross the blood-brain barrier. It can modulate cognitive and neurological functions in mood disorders and is suitable for research in the field of neurodegenerative diseases .

HY-162232

mGluR2 agonist 1	mGluR	Neurological Disease
mGluR2 agonist 1 (Compound 5b) is a potent and selective metabotropic glutamate 2 receptor (mGluR) agonist with an EC₅₀ of 82 nM. mGluR2 agonist 1 can be used for the research of central nervous system (CNS) diseases .

HY-162232A

mGluR2 agonist 1 hydrochloride	mGluR	Neurological Disease
mGluR2 agonist 1 hydrochloride is a potent selective agonist for metabotropic glutamate receptors *mGluR 2* with EC₅₀ of 82 nM .

HY-155088

MK-8768	mGluR	Metabolic Disease
MK-8768 is a highly potent, orally bioavailable and selective class of *mGluR2* negative allosteric modulator (IC₅₀ of 9 .6nM) with excellent brain permeability.

HY-50906

LY404039 2 Publications Verification	mGluR	Neurological Disease
LY404039 is a potent, selective and orally active *mGluR2* and *mGluR3* agonist with K_is of 149 nM and 92 nM for recombinant human mGluR2 and *mGluR3, respectively. LY404039 shows >100-fold selectivity for mGluR2*/3 over other receptors/transproters. LY404039 has antipsychotic and anxiolytic effects .

HY-107457

AZD-8529 1 Publications Verification	mGluR	Neurological Disease
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of *mGluR2, with an EC₅₀* of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

HY-107457A

AZD-8529 mesylate 1 Publications Verification	mGluR	Neurological Disease
AZD-8529 mesylate is a potent, highly selective and orally bioavailable positive allosteric modulator of *mGluR2, with an EC₅₀* of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes .

HY-100838A

L-CCG-I	mGluR	Metabolic Disease
L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for *mGluR2* with an EC₅₀ value of 0.3 nM. L-CCG-I can be used for the research of mGluR family .

HY-114863

PHCCC(4Me) THCCC	mGluR	Neurological Disease
PHCCC(4Me) (THCCC), a PHCCC analog, is a dual *mGluR2* (IC₅₀ of 1.5 μM) negative allosteric modulator and *mGluR3* (EC₅₀ of 8.9 μM) positive allosteric modulator .

HY-19434A

cis-ACPD	iGluR mGluR	Neurological Disease
cis-ACPD is a potent agonist of NMDA receptor, with an IC₅₀ of 3.3 μM. cis-ACPD is also a selective agonist of group II mGluR, with EC₅₀s of 13 μM and 50 μM for *mGluR2* and *mGluR4*, respectively ^[2].

HY-157998

mG2N001	mGluR Src	Others
mG2N001 is a negative allosteric modulator (NAM) (IC₅₀: 93 nM) of the metabotropic glutamate receptor *mGluR2* and binds to *mGluR2* as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope ^[11C]mG2N001 can be used in PET imaging. ^[11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images .

HY-131286A

Talaglumetad hydrochloride LY-544344 hydrochloride	mGluR	Neurological Disease
Talaglumetad hydrochloride is a precursor of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the research of anxiety.

HY-123411

MGS0039 BCI 632	mGluR	Neurological Disease
MGS0039 is a type II group *mGluR* antagonist. MGS0039 has a high affinity for mGluR2 and mGluR3, with K_i values of 2.2 nM and 4.5 nM, respectively. MGS0039 can attenuate the inhibitory effect of glutamate-induced cyclic AMP formation triggered by Forskolin (HY-15371) in CHO cells expressing mGluR2/mGluR3. MGS0039 shows antidepressant-like activity in rats .

HY-163831

AZ12559322	mGluR	Neurological Disease
AZ12559322 is a positive allosteric modulator of *mGluR2, with the K_i* value of 1.31 nM. AZ12559322 can be used in neurological research .

HY-101332

EGLU (2S)-α-Ethylglutamic acid; (2S)-α-EGLU	mGluR	Neurological Disease
EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive *mGluR-2* receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a K_d value of 66 μM. EGLU is an antidepressant agent .

HY-101247

MTPG	mGluR	Neurological Disease
MTPG is a potent *mGluR2* and *mGluR3* antagonist. MTPG can block the induction of brain ischemic tolerance induced by cerebral ischemic preconditioning. MTPG also significantly attenuates the inhibitory effect of L-CCG-1 on the KCl-evoked dopamine release .

HY-15129

O-Phospho-L-serine 2 Publications Verification L-Serine O-phosphate; L-SOP	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-100804

L-Cysteinesulfinic acid	mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-W017230

L-Cysteinesulfinic acid monohydrate	mGluR Endogenous Metabolite	Neurological Disease
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-100617

(S)-4CPG (S)-4-Carboxyphenylglycine	mGluR	Neurological Disease
(S)-4CPG ((S)-4-Carboxyphenylglycine) is a potent *mGluR2* agonist. (S)-4CPG reduces hyperalgesia and allodynia associated with sciatic nerve contraction injury in rats. (S)-4CPG can be used in research on neurological diseases ^[2].

HY-129636

CLH304a (E)-GABAB receptor antagonist 1	GABA Receptor ERK	Neurological Disease
CLH304a (compound 14) is a specific and noncompetitive GABA_B receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC₅₀ of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABA_B receptor ^[2].

HY-122255

LY487379	mGluR	Neurological Disease
LY487379 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research ^[2].

HY-100840A

(RS)-4C3HPG 4-Carboxy-3-hydroxyphenylglycine	mGluR	Neurological Disease
(RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 (mGluR1) in the central nervous system, and it is also an agonist at *mGluR2/3*. (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model ^[2].

HY-15129S

O-Phospho-L-serine-13C3,15N L-Serine O-phosphate-¹³C₃,¹⁵N; L-SOP-¹³C₃,¹⁵N	mGluR Endogenous Metabolite	Neurological Disease
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

HY-103552

LY487379 hydrochloride	mGluR	Neurological Disease
LY487379 hydrochloride is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 hydrochloride potentiates glutamate-stimulated [ ³⁵S]GTPγS binding with EC₅₀ values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 hydrochloride promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 hydrochloride can be used for schizophrenia research ^[2].

HY-118285

Ro4491533	mGluR	Neurological Disease
Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.

HY-100371

(RS)-MCPG 1 Publications Verification alpha-MCPG	mGluR	Neurological Disease
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons ^[2].

HY-129636A

(E/Z)-CLH304a GABAB receptor antagonist 1	GABA Receptor ERK	Neurological Disease
(E/Z)-CLH304a (GABAB receptor antagonist 1) is a mixture of (E)-CLH304a and (Z)-CLH304a. (E)-CLH304a (CLH304a; HY-129636) is a specific and noncompetitive GABA_B receptor negative allosteric modulator (NAM). CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptors ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15129

O-Phospho-L-serine 2 Publications Verification L-Serine O-phosphate; L-SOP	Structural Classification Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite	mGluR Endogenous Metabolite
O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the *group III mGluR* receptors** (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for *mGluR1* and a potent antagonist for *mGluR2* .

HY-100804

L-Cysteinesulfinic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

HY-W017230

L-Cysteinesulfinic acid monohydrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	mGluR Endogenous Metabolite
L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC₅₀s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively .

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HY-P703140

	GRM2 Protein, Human (Sf9, His) GPRC1B; mGluR2	Human	Sf9 insect cells
	GRM2 Protein, Human (Sf9, His) is the recombinant human-derived GRM2, expressed by Sf9 insect cells , with His labeled tag. The total length of GRM2 Protein, Human (Sf9, His) is 475 a.a.,

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HY-15129S

O-Phospho-L-serine-13C3,15N
O-Phospho-L-serine- ¹³C₃, ¹⁵N is the ¹³C- and ¹⁵N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1].

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HY-P83473

	Metabotropic Glutamate Receptor 2 Antibody (YA3218) GRM2; GPRC1B; mGluR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; mGluR3; Metabotropic glutamate receptor 3; mGluR3	WB, IHC-P	Human, Mouse
	Metabotropic Glutamate Receptor 2 Antibody (YA3218) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3218), targeting Metabotropic Glutamate Receptor 2, with a predicted molecular weight of 96 kDa (observed band size: 99 kDa). Metabotropic Glutamate Receptor 2 Antibody (YA3218) can be used for WB, IHC-P experiment in human, mouse background.

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mGluR2

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