2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. Biphenylindanone A

Biphenylindanone A  (Synonyms: BINA)

Cat. No.: HY-15442 Purity: ≥99.0%
SDS COA Handling Instructions

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Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.

For research use only. We do not sell to patients.

Biphenylindanone A Chemical Structure

Biphenylindanone A Chemical Structure

CAS No. : 866823-73-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 435 In-stock
Solution
10 mM * 1 mL in DMSO USD 435 In-stock
Solid
5 mg USD 395 In-stock
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Based on 1 publication(s) in Google Scholar

Biphenylindanone A Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders[1].

IC50 & Target

mGluR2

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
0.38 μM
Compound: 1, BINA
Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay
Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay
[PMID: 23009245]
HEK293-A EC50
441 nM
Compound: BINA
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assay
Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293A cells by calcium mobilization assay
[PMID: 24735492]
In Vitro

Biphenylindanone A (BINA) shows activity on glutamate-induced scintillation proximity assay [3H]IP1 hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Biphenylindanone A Related Antibodies
Molecular Weight

454.56

Formula

C30H30O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(C2=CC=CC(COC3=CC4=C(C(C(C5CCCC5)C4)=O)C(C)=C3C)=C2)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1999 mL 10.9996 mL 21.9993 mL
5 mM 0.4400 mL 2.1999 mL 4.3999 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.12%

SDS (392 KB)

COA (245 KB) LCMS (99 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1999 mL 10.9996 mL 21.9993 mL 54.9982 mL
5 mM 0.4400 mL 2.1999 mL 4.3999 mL 10.9996 mL
10 mM 0.2200 mL 1.1000 mL 2.1999 mL 5.4998 mL
15 mM 0.1467 mL 0.7333 mL 1.4666 mL 3.6665 mL
20 mM 0.1100 mL 0.5500 mL 1.1000 mL 2.7499 mL
25 mM 0.0880 mL 0.4400 mL 0.8800 mL 2.1999 mL
30 mM 0.0733 mL 0.3667 mL 0.7333 mL 1.8333 mL
40 mM 0.0550 mL 0.2750 mL 0.5500 mL 1.3750 mL
50 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1000 mL
60 mM 0.0367 mL 0.1833 mL 0.3667 mL 0.9166 mL
80 mM 0.0275 mL 0.1375 mL 0.2750 mL 0.6875 mL
100 mM 0.0220 mL 0.1100 mL 0.2200 mL 0.5500 mL
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Biphenylindanone A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Biphenylindanone A866823-73-6BINAmGluRMetabotropic glutamate receptorsmGluR2hmGluR2potentiatorneurologicaldisorderInhibitorinhibitorinhibit

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