2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. mGluR2 modulator 5

mGluR2 modulator 5 (Compound 11) is an orally active, selective mGluR2 negative allosteric modulator with an IC50 of 8.9 nM. Pharmacokinetic studies in rats show that mGluR2 modulator 5 can effectively cross the blood-brain barrier. It can modulate cognitive and neurological functions in mood disorders and is suitable for research in the field of neurodegenerative diseases.

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mGluR2 modulator 5 Chemical Structure

mGluR2 modulator 5 Chemical Structure

CAS No. : 1639898-35-3

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mGluR2 modulator 5 Related Antibodies

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Description

mGluR2 modulator 5 (Compound 11) is an orally active, selective mGluR2 negative allosteric modulator with an IC50 of 8.9 nM. Pharmacokinetic studies in rats show that mGluR2 modulator 5 can effectively cross the blood-brain barrier. It can modulate cognitive and neurological functions in mood disorders and is suitable for research in the field of neurodegenerative diseases[1].

IC50 & Target

mGluR2

8.9 nM (IC50)

Molecular Weight

386.37

Formula

C20H17F3N4O
CAS No.
SMILES

CC1=NC=CC(C2=C(C(N(C3=CC=C(C(F)(F)F)C=C3)C[C@@H]4C)=O)N4N=C2)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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mGluR2 modulator 5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mGluR2 modulator 51639898-35-3mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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