1. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  2. mGluR Endogenous Metabolite
  3. L-Cysteinesulfinic acid

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.

For research use only. We do not sell to patients.

L-Cysteinesulfinic acid Chemical Structure

L-Cysteinesulfinic acid Chemical Structure

CAS No. : 1115-65-7

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5 mg USD 38 In-stock
10 mg USD 60 In-stock
25 mg USD 120 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of L-Cysteinesulfinic acid:

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  • Biological Activity

  • Purity & Documentation

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Description

L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

IC50 & Target

mGluR1

3.92 (pEC50)

mGluR2

3.9 (pEC50)

mGluR4

2.7 (pEC50)

mGluR5

4.6 (pEC50)

mGluR6

4.0 (pEC50)

mGluR8

3.94 (pEC50)

Human Endogenous Metabolite

 

In Vitro

L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

153.16

Formula

C3H7NO4S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CS(O)=O)C(O)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (816.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5291 mL 32.6456 mL 65.2912 mL
5 mM 1.3058 mL 6.5291 mL 13.0582 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.81%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.5291 mL 32.6456 mL 65.2912 mL 163.2280 mL
5 mM 1.3058 mL 6.5291 mL 13.0582 mL 32.6456 mL
10 mM 0.6529 mL 3.2646 mL 6.5291 mL 16.3228 mL
15 mM 0.4353 mL 2.1764 mL 4.3527 mL 10.8819 mL
20 mM 0.3265 mL 1.6323 mL 3.2646 mL 8.1614 mL
25 mM 0.2612 mL 1.3058 mL 2.6116 mL 6.5291 mL
30 mM 0.2176 mL 1.0882 mL 2.1764 mL 5.4409 mL
40 mM 0.1632 mL 0.8161 mL 1.6323 mL 4.0807 mL
50 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2646 mL
60 mM 0.1088 mL 0.5441 mL 1.0882 mL 2.7205 mL
80 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
100 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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L-Cysteinesulfinic acid
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