2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. PHCCC(4Me)

PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator.

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PHCCC(4Me) Chemical Structure

PHCCC(4Me) Chemical Structure

CAS No. : 1259532-01-8

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Based on 1 publication(s) in Google Scholar

PHCCC(4Me) Related Antibodies

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Description

PHCCC(4Me) (THCCC), a PHCCC analog, is a dual mGluR2 (IC50 of 1.5 μM) negative allosteric modulator and mGluR3 (EC50 of 8.9 μM) positive allosteric modulator[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
1.5 μM
Compound: 3
Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay
Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay
[PMID: 21105727]
HEK293 EC50
8.9 μM
Compound: 3
Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay
Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay
[PMID: 21105727]
In Vitro

PHCCC(4Me) (THCCC; Compound 3) shows micromolar affinity for mGluR2, with a Ki value of 0.6 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PHCCC(4Me) Related Antibodies
Molecular Weight

308.33

Formula

C18H16N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C(C=C1)C)C23CC2/C(C4=C(C=CC=C4)O3)=N\O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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PHCCC(4Me) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHCCC(4Me)1259532-01-8THCCCmGluRMetabotropic glutamate receptorsmGluR2mGluR3negativepositiveallostericmodulatorPHCCCNAMPAMInhibitorinhibitorinhibit

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HY-114863
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