2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (RS)-MCPG

(RS)-MCPG  (Synonyms: alpha-MCPG)

Cat. No.: HY-100371 Purity: 99.05%
COA Handling Instructions

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(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.

For research use only. We do not sell to patients.

(RS)-MCPG Chemical Structure

(RS)-MCPG Chemical Structure

CAS No. : 146669-29-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 87 In-stock
Solution
10 mM * 1 mL in DMSO USD 87 In-stock
Solid
1 mg USD 38 In-stock
5 mg USD 80 In-stock
10 mg USD 110 In-stock
25 mg USD 240 In-stock
50 mg USD 430 In-stock
100 mg USD 780 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of (RS)-MCPG:

(RS)-MCPG Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (RS)-MCPG

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

IC50 & Target[1]

mGluR

 

In Vitro

MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(RS)-MCPG Related Antibodies
In Vivo

(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

209.20

Formula

C10H11NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

1M NaOH : 100 mg/mL (478.01 mM; ultrasonic and adjust pH to 10 with NaOH)

DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7801 mL 23.9006 mL 47.8011 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.05%

COA (249 KB) HNMR (246 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 4.7801 mL 23.9006 mL 47.8011 mL 119.5029 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL 23.9006 mL
10 mM 0.4780 mL 2.3901 mL 4.7801 mL 11.9503 mL
15 mM 0.3187 mL 1.5934 mL 3.1867 mL 7.9669 mL
20 mM 0.2390 mL 1.1950 mL 2.3901 mL 5.9751 mL
25 mM 0.1912 mL 0.9560 mL 1.9120 mL 4.7801 mL
1M NaOH 30 mM 0.1593 mL 0.7967 mL 1.5934 mL 3.9834 mL
40 mM 0.1195 mL 0.5975 mL 1.1950 mL 2.9876 mL
50 mM 0.0956 mL 0.4780 mL 0.9560 mL 2.3901 mL
60 mM 0.0797 mL 0.3983 mL 0.7967 mL 1.9917 mL
80 mM 0.0598 mL 0.2988 mL 0.5975 mL 1.4938 mL
100 mM 0.0478 mL 0.2390 mL 0.4780 mL 1.1950 mL
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(RS)-MCPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(RS)-MCPG146669-29-6alpha-MCPGmGluRMetabotropic glutamate receptorsgroupI/IImetabotropicglutamatereceptorhippocampalneuronsmGluR1mGluR5mGluR2mGluR3Inhibitorinhibitorinhibit

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