2. Signaling Pathways
  3. Epigenetics
  4. Epigenetic Reader Domain
  5. BRD2 Isoform
  6. BRD2 Degrader

BRD2 Degrader

BRD2 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-170390
    AB3067
    		Degrader
    AB3067 is a PROTAC degrader for BET protein, that recruits two different E3 ligase Cereblon and VHL with good affinity (IC50=559 nM for VHL in live HEK293; IC50=190 nM for CRBN in live HEK293), and degrades BRD2, BRD3, BRD4 and CRBN with DC50 of 2.1~2.3, 1.6, 15 and 75 nM, respectively. AB3067 inhibits the proliferation of RKO cell with an EC50 of 111 nM. (Pink: ligand for target protein (HY-131633A); Black: linker (HY-170391); Blue: ligand for E3 ligase VHL (HY-112078) and CRBN(HY-W998346))