2. Signaling Pathways
  3. Neuronal Signaling
  4. Choline Kinase

Choline Kinase

Choline Kinase; CK; ChoK; choline phosphokinase

Choline kinase (also known as CK, ChoK and choline phosphokinase) is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine (PC) biosynthesis. Phosphatidylcholine (PC) is synthesized through the Kennedy pathway. In the initial step, choline is converted to phosphocholine by Choline Kinase in a reaction catalyzed by one of two enzymatic forms: choline kinase α (CHKα) and choline kinase β (CHKβ). The CHKA gene produces two proteins, CHKα1 and CHKα2, through alternative splicing. All isoforms of choline kinases catalyze the same biochemical reaction: the formation of phosphocholine. CHKα and CHKβ form homodimers and heterodimers. The expression and activity of Choline Kinases are regulated during transcription, at the mRNA level and by post-translational modification. CHKα expression is directly regulated by miR-367-3p11 and miR-876-5p. Choline kinase activity can be regulated by various proteins acting on CHKα or CHKβ. Choline kinase activity can also be regulated by changes in CHKα protein stability. Choline kinase plays an important role in various tumor types[1].

Choline Kinase Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-122675
    ACG416B
    		Inhibitor 98.99%
    ACG416B (compound 18) is a potent inhibitor of ChoK (choline kinase) with an IC50 of 0.4 μM. ACG416B renders higher ChoK inhibitory and antiproliferative activities against the HT-29 human colon cancer cell.
    ACG416B
  • HY-120337
    V-11-0711
    		Inhibitor 98.54%
    V-11-0711 is a potent and selective choline kinase alpha (ChoKα) inhibitor with an IC50 of 20 nM. V-11-0711 causes a reversible growth arrest in HeLa cells.
    V-11-0711
  • HY-162799
    ChoKα inhibitor-6
    		Inhibitor
    ChoKα inhibitor-6 (compound Fa22) is a less specific ChoKα1 inhibitor with antitumor activity.
    ChoKα inhibitor-6
  • HY-170805
    UNC0737
    		Inhibitor
    UNC0737 is an orthosteric choline kinase inhibitor. UNC0737 is also a poor inhibitor of G9a (IC50 = 5000 nM) and GLP (IC50 > 10000 nM) in the SAHH-coupled assays.
    UNC0737
  • HY-162800
    ChoKα inhibitor-7
    		Inhibitor
    ChoKα inhibitor-7 (compound PL48) is a less specific ChoKα1 inhibitor with antitumor activity.
    ChoKα inhibitor-7
  • HY-114081A
    Hemicholinium chloride
    		Inhibitor
    Hemicholinium chloride (HC-3) is a choline kinase (ChoK) inhibitor. Hemicholinium chloride Hemicholinium chloride induces ataxia and muscular weakness.
    Hemicholinium chloride