2. Apoptosis
  3. Apoptosis
  4. Anticancer agent 39

Anticancer agent 39 (compound B12), a fluorescent derivative of Jiyuan Oridonin A (JOA), induces the collapse of mitochondrial membrane potential (MMP)and thus induced apoptosis.Anticancer agent 39 inhibits cell cloning and migration.Anticancer agent 39 exhibits promising anti-proliferative activity against HGC-27 cells with IC50 value of 0.39 μM.

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Anticancer agent 39 Chemical Structure

Anticancer agent 39 Chemical Structure

CAS No. : 2762426-00-4

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Anticancer agent 39 Related Antibodies

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Description

Anticancer agent 39 (compound B12), a fluorescent derivative of Jiyuan Oridonin A (JOA), induces the collapse of mitochondrial membrane potential (MMP)and thus induced apoptosis.Anticancer agent 39 inhibits cell cloning and migration.Anticancer agent 39 exhibits promising anti-proliferative activity against HGC-27 cells with IC50 value of 0.39 μM[1].

Cellular Effect
Cell Line Type Value Description References
HGC-27 IC50
3.11 μM
Compound: B6
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human HGC-27 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
MGC-803 IC50
2.18 μM
Compound: B6
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
PC-3 IC50
0.81 μM
Compound: B6
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
SW1990 IC50
1.64 μM
Compound: B6
Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human SW1990 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
TE-1 IC50
1.44 μM
Compound: B6
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
Antiproliferative activity against human TE-1 cells assessed as inhibition of cell growth measured after 72 hrs by SRB assay
[PMID: 34954589]
Molecular Weight

896.08

Formula

C50H65N5O10
CAS No.
SMILES

O[C@@]([C@]1([H])C2=C)([H])[C@@]3(C2=O)[C@]([C@H](C1)O)([H])C4(CCCC(C)5C)[C@]5([H])C[C@@]3([H])O[C@H]4OCCCC(N=N6)=CN6CCOCCOCCOCCN(C7=O)C(C8=CC=C(N9CCCCC9)C%10=C8C7=CC=C%10)=O
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Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Anticancer agent 39 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 392762426-00-4Anticancer agent39Anticancer agent-39ApoptosisJiyuan?Oridonin?Amitochondrial membrane potentialMMPcloningmigrationproliferative activityHGC-27Inhibitorinhibitorinhibit

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