Mediator of RNA polymerase II transcription subunit 29

Definition:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

References:

[1]. Yuequn Wang, et al. IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1330-8. [Content Brief]

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