PR domain zinc finger protein 5

Definition:

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.

References:

[1]. Qingdong Deng, et al. PRDM5 is silenced in human cancers and has growth suppressive activities. Oncogene. 2004 Jun 17;23(28):4903-10. [Content Brief]

[2]. Zhijun Duan, et al. Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5. Mol Cell Biol. 2007 Oct;27(19):6889-902. [Content Brief]

[3]. Emma M M Burkitt Wright, et al. Mutations in PRDM5 in brittle cornea syndrome identify a pathway regulating extracellular matrix development and maintenance. Am J Hum Genet. 2011 Jun 10;88(6):767-777. [Content Brief]

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