BTL-105

Cat. No.: HY-129780: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BTL-105 is a monobiotinylated Phos-tag derivative for the detection of phosphopeptides and phosphoproteins.

For research use only. We do not sell to patients.

BTL-105 Chemical Structure

CAS No. : 945007-11-4

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 581	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO	USD 581	Ask For Quote & Lead Time
Solid
5 mg	USD 380	Ask For Quote & Lead Time
10 mg	USD 600	Ask For Quote & Lead Time
25 mg	USD 1150	Ask For Quote & Lead Time
50 mg	USD 1800	Ask For Quote & Lead Time
100 mg	USD 2850	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
Purity & Documentation
References
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Description

BTL-105 is a monobiotinylated Phos-tag derivative for the detection of phosphopeptides and phosphoproteins^[1].

Molecular Weight

880.11

Formula

C₄₆H₆₁N₁₁O₅S

CAS No.

945007-11-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCCCCC(NCCNC(C1=CC=C(CN(CC(O)CN(CC2=NC=CC=C2)CC3=NC=CC=C3)CC4=NC=CC=C4)N=C1)=O)=O)CCCC[C@@H]5SC[C@]([C@]5([H])N6)([H])NC6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (113.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1362 mL	5.6811 mL	11.3622 mL
5 mM	0.2272 mL	1.1362 mL	2.2724 mL
10 mM	0.1136 mL	0.5681 mL	1.1362 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (2.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.35%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (255 KB) HNMR (344 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Tohru Koike, et al. Method for measuring a surface plasmon resonance and noble metal compound used for the same. US20090185181A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1362 mL	5.6811 mL	11.3622 mL	28.4055 mL
	5 mM	0.2272 mL	1.1362 mL	2.2724 mL	5.6811 mL
	10 mM	0.1136 mL	0.5681 mL	1.1362 mL	2.8406 mL
	15 mM	0.0757 mL	0.3787 mL	0.7575 mL	1.8937 mL
	20 mM	0.0568 mL	0.2841 mL	0.5681 mL	1.4203 mL
	25 mM	0.0454 mL	0.2272 mL	0.4545 mL	1.1362 mL
	30 mM	0.0379 mL	0.1894 mL	0.3787 mL	0.9469 mL
	40 mM	0.0284 mL	0.1420 mL	0.2841 mL	0.7101 mL
	50 mM	0.0227 mL	0.1136 mL	0.2272 mL	0.5681 mL
	60 mM	0.0189 mL	0.0947 mL	0.1894 mL	0.4734 mL
	80 mM	0.0142 mL	0.0710 mL	0.1420 mL	0.3551 mL
	100 mM	0.0114 mL	0.0568 mL	0.1136 mL	0.2841 mL

BTL-105 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTL-105945007-11-4BTL105BTL 105OthersInhibitorinhibitorinhibit

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