CFI-400437

Cat. No.: HY-120279A: FAQs
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CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC₅₀ of 0.6 nM).

For research use only. We do not sell to patients.

CFI-400437 Chemical Structure

CAS No. : 1169211-37-3

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PLK1 PLK2 PLK3 PLK4

Biological Activity
Purity & Documentation
References
Customer Review

Description	CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC₅₀ of 0.6 nM)^[1].
In Vitro	CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB231 cell growth^[1]. CFI-400437 inhibits Aurora A, Aurora B, KDR and FLT-3 with IC₅₀s of 0.37, 0.21, 0.48, and 0.18 µM, respectively, i.e. two orders of magnitude higher than its IC₅₀ of 0.6 nM against PLK4^[1]. CFI-400437 inhibits both AURKB and AURKC at concentrations <15 nM^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. CFI-400437 Related Antibodies
In Vivo	CFI-400437 (25 mg/kg, ip, once daily for 21 d) exhibits antitumor activity against MDA-MB-468 breast cancer mouse xenograft model^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	492.57
Formula	C₂₉H₂₈N₆O₂
CAS No.	1169211-37-3
SMILES	O=C1NC2=C(C=C(OC)C=C2)/C1=C\C3=CC4=C(C=C3)C(/C=C/C5=CC=C(N6CCN(C)CC6)N=C5)=NN4
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Radoslaw Laufer, et al. The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents. J Med Chem. 2013 Aug 8;56(15):6069-87. [Content Brief] [2]. Amreena Suri, et al. Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer. Int J Mol Sci. 2019 Apr 29;20(9):2112. [Content Brief]

CFI-400437 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CFI-4004371169211-37-3CFI400437CFI 400437Polo-like Kinase (PLK)PLK4breastcancerMDA-MB-468AURKBAURKCInhibitorinhibitorinhibit

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