Clascoterone-d₆  (Synonyms: Cortexolone 17 alpha-propionate-d₆; Cortexolone 17α-propionate-d₆; CB-03-01-d₆)

Clascoterone-d₆ (Cortexolone 17 alpha-propionate-d₆) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist^[1].

408.56

C₂₄H₂₈D₆O₅

19608-29-8

CCC(O[C@@]1(CC[C@]2([C@@]3(CC(C4=C(C(C([2H])(C[C@@]4([C@]3(CC[C@]12C)[H])C)[2H])=O)[2H])[2H])[H])[H])C(C([2H])(O)[2H])=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Trifu V, et al. Cortexolone 17伪-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0路05% cream. Br J Dermatol. 2011 Jul;165(1):177-83.  [Content Brief]

  [3]. Trifu V, et al. Cortexolone 17α-propionate 1% cream, a new potent antiandrogen for topical treatment of acne vulgaris. A pilot randomized, double-blind comparative study vs. placebo and tretinoin 0·05% cream. Br J Dermatol. 2011 Jul;165(1):177-83.

  [4]. Celasco G, et al. Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.  [Content Brief]