Dorzolamide-d₅(hydrochloride)  (Synonyms: L671152 hydrochloride-d₅; MK507 hydrochlorid-d₅)

Dorzolamide-d₅(hydrochloride) (L671152 hydrochloride-d₅) is deuterium labeled Dorzolamide (hydrochloride). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity^[1][2].

365.93

C₁₀H₁₂D₅ClN₂O₄S₃

2749856-75-3

130693-82-2

O=S1([C@H](C[C@@H](C2=C1SC(S(N)(=O)=O)=C2)NC([2H])(C([2H])([2H])[2H])[2H])C)=O.Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Belal M Ali, et al. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1271-82.  [Content Brief]

  [3]. J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60.  [Content Brief]

  [4]. Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8.  [Content Brief]