2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR/HER2-IN-15

EGFR/HER2-IN-15, a dihydropyrimidine, is a potent EGFR/HER2 inhibitor. EGFR/HER2-IN-15 significantly inhibits EGFRwt activity with an IC50 of 37.21 nM. EGFR/HER2-IN-15 has anticaner effects.

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EGFR/HER2-IN-15 Chemical Structure

EGFR/HER2-IN-15 Chemical Structure

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EGFR/HER2-IN-15 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

EGFR/HER2-IN-15, a dihydropyrimidine, is a potent EGFR/HER2 inhibitor. EGFR/HER2-IN-15 significantly inhibits EGFRwt activity with an IC50 of 37.21 nM. EGFR/HER2-IN-15 has anticaner effects[1].

IC50 & Target[1]

EGFR (WT)

37.21 nM (IC50)

In Vitro

At a concentration of 1000 nM EGFR/HER2-IN-15 (compound 21) shows 98.51% and 96.79% inhibition of EGFR and HER2 expression[1].
EGFR/HER2-IN-15 inhibits MCF-7 breast cancer cells with an IC50 of 9.38 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR/HER2-IN-15 Related Antibodies
Molecular Weight

503.55

Formula

C28H29N3O6
SMILES

O=C1NC(C)=C(C(NC2=CC=C(OC)C=C2OC)=O)C(C3=CC(OC)=C(OCC4=CC=CC=C4)C=C3)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/HER2-IN-15 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/HER2-IN-15EGFREpidermal growth factor receptorErbB-1HER1EGFR/HER2 inhibitordihydropyrimidineanticaner effectsInhibitorinhibitorinhibit

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EGFR/HER2-IN-15
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