2. Immunology/Inflammation
  3. IFNAR
  4. Emapalumab

Emapalumab  (Synonyms: NI-0501)

Cat. No.: HY-P99191 Purity: 97.56%
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Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH).

For research use only. We do not sell to patients.

CAS No. : 1709815-23-5

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1 mg USD 220 In-stock
5 mg USD 660 In-stock
10 mg USD 1120 In-stock
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Based on 1 publication(s) in Google Scholar

Emapalumab Related Antibodies

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Description

Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH)[1].

Isotype

Human IgG1 lambda2
Recommend Isotype Controls
Species

Human
In Vitro

Emapalumab (NI-0501) impairs IFNcR1 and IFNc-Receptor-2 (IFNcR2) interaction induced by IFNc at the cell surface.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Emapalumab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Emapalumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 lambda2
Purity & Documentation
References
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Emapalumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Emapalumab1709815-23-5NI-0501NI0501NI 0501IFNARInterferon-α/β receptorInterferon-alpha/beta receptorhumanized monoclonal antibodyhemophagocytic lymphohistiocytosisIFNc-Receptor-2Inhibitorinhibitorinhibit

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