2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. ERK5-IN-3

ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM.

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ERK5-IN-3 Chemical Structure

ERK5-IN-3 Chemical Structure

CAS No. : 1888305-85-8

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ERK5-IN-3 Related Antibodies

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Description

ERK5-IN-3 (compound 33j) is a potent and selective ERK5 (extracellular signal-related kinase 5) inhibitor, with an IC50 of 6 nM. ERK5-IN-3 shows antiproliferation activity against Hela cells, with an IC50 of 31 nM[1].

IC50 & Target

ERK5

6 ± 1 nM (IC50)

In Vivo

ERK5-IN-3 (compound 33j) (10 mg/kg, i.v. and p.o, once) has low clearance (CL=20 mL/min/kg) and low oral bioavailability (F%=9%), with terminal elimination half-lives of 263 min[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

489.37

Formula

C24H23Cl2FN4O2
CAS No.
SMILES

O=C(C1=CC(C(C2=C(Cl)C=CC(Cl)=C2F)=O)=CN1)NC3=CC=C(CC4CCN(C)CC4)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ERK5-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERK5-IN-31888305-85-8ERKExtracellular signal regulated kinasesHela cellsmitogen-activated protein kinase pathwayinhibitionoral exposureMAPKcancerInhibitorinhibitorinhibit

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