NEU3 - neuraminidase 3 Gene

Homo sapiens

Also known as SIAL3

Gene ID: 10825 | Gene type: protein coding

About NEU3

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:74,980,515-75,020,676 (from NCBI)

This gene has 7 transcripts (splice variants), 333 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 5.8), prostate (RPKM 5.1) and 25 other tissues.

Summary

This gene product belongs to a family of glycohydrolytic Enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]

NEU3 Products(9)

mRNA	Protein	Name
NM_001367860.1	NP_001354789.1	sialidase-3 isoform a
NM_001367861.1	NP_001354790.1	sialidase-3 isoform b
NM_001367862.1	NP_001354791.1	sialidase-3 isoform b
NM_001367863.1	NP_001354792.1	sialidase-3 isoform c
NM_001367864.1	NP_001354793.1	sialidase-3 isoform c
NM_001367865.1	NP_001354794.1	sialidase-3 isoform d
NM_001367866.1	NP_001354795.1	sialidase-3 isoform e
NM_001367867.2	NP_001354796.1	sialidase-3 isoform f
NM_006656.6	NP_006647.3	sialidase-3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-sialidase activity	IDA IDA: Inferred from direct assay	12730204	GOA
enables exo-alpha-sialidase activity	IDA IDA: Inferred from direct assay	10861246	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17334392	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within carbohydrate metabolic process	IDA IDA: Inferred from direct assay	12730204	GOA
involved in ganglioside catabolic process	IDA IDA: Inferred from direct assay	10861246	GOA
involved in negative regulation of clathrin-dependent endocytosis	IDA IDA: Inferred from direct assay	26251452	GOA
involved in oligosaccharide catabolic process	IDA IDA: Inferred from direct assay	10861246	GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17334392	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	26251452	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	26251452	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12730204	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	26251452	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEU3 Protein Structure

BNR_2

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

sialidase-3

N-acetyl-alpha-neuraminidase 3

Related Diseases

Diseases

Alias

Galactosialidosis

Goldberg Syndrome	Neuraminidase Deficiency With Beta-Galactosidase Deficiency
Ppca Deficiency	GSL
Lysosomal Protective Protein Deficiency	Cathepsin A Deficiency
Neuraminidase/Beta-Galactosidase Expression	Protective Protein/Cathepsin A Deficiency
Ngbe	Cathepsin A Deficiency Of
Lysosomal Protective Protein Deficiency Of	Deficiency Of Cathepsin A
Neuraminidase Beta-Galactosidase Deficiency	Protective Protein Cathepsin A Deficiency

Glycoproteinosis

Sialidosis	Mucolipidosis Type I
Mucolipidoses	Cherry Red Spot Myoclonus Syndrome
Mucolipidosis I	Myoclonus Cherry Red Spot Syndrome
Type I Mucolipidosis	Lipomucopolysaccharidosis
Disorders Of Glycoprotein Metabolism	Glycoprotein Storage Disorder

Mucolipidosis

Tay-Sachs Disease

Hexosaminidase A Deficiency	TSD
Hexa Deficiency	Gm2 Gangliosidosis, Type 1
Hexosaminidase Alpha-Subunit Deficiency	Gm2-Gangliosidosis, Several Forms
Gm2-Gangliosidosis, B, B1, Ab Variant	B Variant Gm2 Gangliosidosis
Sphingolipidosis, Tay-Sachs	Gm2-Gangliosidosis, Type I
B Variant Gm2-Gangliosidosis	Hex A Pseudodeficiency
Hexa Disorders	Beta-Hexosaminidase A Deficiency
Gm2 Gangliosidosis, Type I	Gangliosidosis Gm2 , Type 1
Gm2 Gangliosidosis, B, B1 Variant	Gm2-Gangliosidosis 1
GM2G1	Gm2-Gangliosidosis B Variant
Tay-Sachs Disease Pseudo-Ab Variant	Tay-Sachs Disease Variant B1
Gangliosidoses, Gm2

Gm2-Gangliosidosis, Ab Variant

Hexosaminidase Activator Deficiency	Tay-Sachs Disease, Ab Variant
Gm2 Gangliosidosis, Ab Variant	Gm2 Activator Deficiency
Tay-Sachs Disease, Variant Ab	Tay-Sachs Disease Ab Variant
Ab Variant Gm2-Gangliosidosis	Tay-Sachs Variant Ab
Ab Variant	Activator Deficiency/Gm2 Gangliosidosis
Activator-Deficient Tay-Sachs Disease	Gm2 Activator Deficiency Disease
Gm2 Gangliosidosis, Type Ab	Gm2-Gangliosidosis Ab
GM2GAB	Gm2-Gangliosidosis Ab Variant
Gangliosidosis Gm2 Ab Variant	Gm2-Gangliosidosis, Variant Ab

Gm2 Gangliosidosis

Gangliosidosis Gm2

Gangliosidoses, Gm2

Sandhoff Disease

Total Hexosaminidase Deficiency	Hexosaminidases A And B Deficiency
Sandhoff Disease, Infantile, Juvenile, And Adult Forms	Beta-Hexosaminidase-Beta-Subunit Deficiency
Gm2 Gangliosidosis, Type 2	Hexosaminidase A And B Deficiency Disease
Sandhoff-Jatzkewitz-Pilz Disease	Gm2 Gangliosidosis, Type Ii
Sandhoff Disease, Infantile Form	Sandhoff Disease, Adult Form
Sandhoff Disease, Juvenile Form	Gm2-Gangliosidosis, Type Ii
Sandhoff Jatzkewitz Disease	Type Ii Gm2 Gangliosidosis
Gm2 Gangliosidosis, 0 Variant	Gm2 Gangliosidosis 0 Variant
Hexosaminidases A And B Deficiency, Infantile Form	Infantile Gm2 Gangliosidosis 0 Variant
Adult Gm2 Gangliosidosis 0 Variant	Hexosaminidases A And B Deficiency, Adult Form
Hexosaminidases A And B Deficiency, Juvenile Form	Juvenile Gm2 Gangliosidosis 0 Variant
Gm2-Gangliosidosis 2	GM2G2
Hexosaminidase A And B Deficiency	Sd

Ovarian Clear Cell Adenocarcinoma

Gangliosidosis

Gangliosidoses

Gm1 Gangliosidosis

Beta-Galactosidase Deficiency	Gangliosidosis Gm1
Deficiency Of Beta-Galactosidase	Beta Galactosidase 1 Deficiency
Beta-Galactosidosis	Glb 1 Deficiency
Beta-Galactosidase-1 Deficiency	Beta-Galactosidase-1 Deficiency
Glb1 Deficiency	Landing Disease
Gangliosidosis, Gm1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125798	2,3-Dehydro-2-deoxy-N-acetylneuraminic acid	Inhibitor	≥99.0%	Unkown
HY-161943	NEU3-IN-1	Inhibitor	/	Unkown
HY-RS09217	NEU3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NEU3	MGD	MGI:1355305
Canis familiaris	NEU3	VGNC	VGNC:52272
Macaca mulatta	NEU3	VGNC	VGNC:75318
Rattus norvegicus	NEU3	RGD	RGD:619881
Felis catus	NEU3	VGNC	VGNC:81972
Bos taurus	NEU3	VGNC	VGNC:54889

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