2. Gene
  3. NPFFR2 - neuropeptide FF receptor 2 Gene

NPFFR2 - neuropeptide FF receptor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPR74; NPFF2; NPGPR; HLWAR77

Gene ID: 10886 | Gene type: protein coding

About NPFFR2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:72,032,000-72,148,305 (from NCBI)

This gene has 5 transcripts (splice variants), 254 orthologues and 16 paralogues. Biased expression in placenta (RPKM 1.4), thyroid (RPKM 0.2) and 7 other tissues.

Summary

This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

NPFFR2 Products(3)

mRNA Protein Name
NM_001144756.2 NP_001138228.1 neuropeptide FF receptor 2 isoform 3
NM_004885.3 NP_004876.3 neuropeptide FF receptor 2 isoform 1
NM_053036.3 NP_444264.1 neuropeptide FF receptor 2 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables neuropeptide receptor activity IDA
IDA: Inferred from direct assay
11024015 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
11024015 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
11024015 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPFFR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (164 - 435)

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  • 522 a.a.
Protein Preferred Names Protein Names

neuropeptide FF receptor 2

G-protein coupled receptor 74

Related Diseases

Diseases Alias
Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism
Nutmeg Liver

Chronic Passive Congestion Of Liver
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P10394 DP32 Antagonist / Unkown
HY-P10395 DP50 Antagonist / Unkown
HY-161405 NPFF1-R antagonist 1 Inhibitor / Unkown
HY-P10377 GUB03385 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NPFFR2 VGNC VGNC:43917
Macaca mulatta NPFFR2 VGNC VGNC:75295
Felis catus NPFFR2 VGNC VGNC:67441
Mus musculus NPFFR2 MGD MGI:1860130
Rattus norvegicus NPFFR2 RGD RGD:620168
Bos taurus NPFFR2 VGNC VGNC:32200