UGT2A1 - UDP glucuronosyltransferase family 2 member A1 complex locus Gene

Homo sapiens

Also known as UDPGT2A1

Gene ID: 10941 | Gene type: protein coding

About UGT2A1

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:69,588,417-69,653,247 (from NCBI)

This gene has 7 transcripts (splice variants), 1196 orthologues and 21 paralogues. Biased expression in kidney (RPKM 2.3), liver (RPKM 2.2) and 1 other tissue.

Summary

The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded Enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 Infection. [provided by RefSeq, Jan 2022]

UGT2A1 Products(5)

mRNA	Protein	Name
NM_001252274.3	NP_001239203.2	UDP-glucuronosyltransferase 2A1 isoform 2 precursor
NM_001252275.3	NP_001239204.2	UDP-glucuronosyltransferase 2A1 isoform 3 precursor
NM_001301239.2	NP_001288168.1	UDP-glucuronosyltransferase 2A1 isoform 4 precursor
NM_001389565.1	NP_001376494.1	UDP-glucuronosyltransferase 2A1 isoform 5 precursor
NM_006798.5	NP_006789.3	UDP-glucuronosyltransferase 2A1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucuronosyltransferase activity	IDA IDA: Inferred from direct assay	10359671	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid metabolic process	IDA IDA: Inferred from direct assay	23756265	GOA
involved in cellular glucuronidation	IDA IDA: Inferred from direct assay	19858781	GOA
involved in sensory perception of chemical stimulus	IDA IDA: Inferred from direct assay	10359671	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UGT2A1 Protein Structure

UDPGT

0
100
200
300
400
527 a.a.

Protein Preferred Names

Protein Names

UDP-glucuronosyltransferase 2A1

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15434	UGT2A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UGT2A1	MGD	MGI:2149905
Rattus norvegicus	UGT2A1	RGD	RGD:69432

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