SGPP2 - sphingosine-1-phosphate phosphatase 2 Gene

Homo sapiens

Also known as SPP2; SPPase2

Gene ID: 130367 | Gene type: protein coding

About SGPP2

Cytogenetic location: 2q36.1 Genomic coordinates (GRCh38): 2:222,423,988-222,562,621 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 13.7), esophagus (RPKM 12.0) and 18 other tissues.

Summary

The protein encoded by this gene is a transmembrane protein that degrades the bioactive signaling molecule sphingosine 1-phosphate. The encoded protein is induced during inflammatory responses and has been shown to be downregulated by the microRNA-31 tumor suppressor. Alternative splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

SGPP2 Products(3)

mRNA	Protein	Name
NM_001320833.2	NP_001307762.1	sphingosine-1-phosphate phosphatase 2 isoform b
NM_001320834.2	NP_001307763.1	sphingosine-1-phosphate phosphatase 2 isoform b
NM_152386.4	NP_689599.2	sphingosine-1-phosphate phosphatase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sphingosine-1-phosphate phosphatase activity	IDA IDA: Inferred from direct assay	12411432	GOA
enables sphingosine-1-phosphate phosphatase activity	IMP IMP: Inferred from mutant phenotype	27059959	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in sphingosine metabolic process	IDA IDA: Inferred from direct assay	12411432	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12411432	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SGPP2 Protein Structure

PAP2

0
100
200
300
399 a.a.

Protein Preferred Names

Protein Names

sphingosine-1-phosphate phosphatase 2

sphingosine 1-phosphate phosphohydrolase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12811	SGPP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SGPP2	RGD	RGD:1565739
Canis familiaris	SGPP2	VGNC	VGNC:57395
Bos taurus	SGPP2	VGNC	VGNC:54481
Felis catus	SGPP2	VGNC	VGNC:65084
Mus musculus	SGPP2	MGD	MGI:3589109
Macaca mulatta	SGPP2	VGNC	VGNC:77278

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