CLYBL - citramalyl-CoA lyase Gene

Homo sapiens

Also known as CLB

Gene ID: 171425 | Gene type: protein coding

About CLYBL

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,606,690-99,909,444 (from NCBI)

This gene has 9 transcripts (splice variants) and 196 orthologues. Broad expression in kidney (RPKM 2.9), liver (RPKM 2.6) and 22 other tissues.

Summary

Enables (S)-citramalyl-CoA lyase activity; magnesium ion binding activity; and malate synthase activity. Involved in protein homotrimerization and regulation of cobalamin metabolic process. Predicted to be located in mitochondrion. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

CLYBL Products(9)

mRNA	Protein	Name
NM_001393355.1	NP_001380284.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_001393356.1	NP_001380285.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393357.1	NP_001380286.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393358.1	NP_001380287.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393359.2	NP_001380288.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393360.1	NP_001380289.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_001393361.1	NP_001380290.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_001393362.1	NP_001380291.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_206808.5	NP_996531.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables (S)-citramalyl-CoA lyase activity	IDA IDA: Inferred from direct assay	29056341	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	24334609	GOA
enables malate synthase activity	IDA IDA: Inferred from direct assay	24334609	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	29056341	GOA
involved in regulation of cobalamin metabolic process	IDA IDA: Inferred from direct assay	29056341	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLYBL Protein Structure

HpcH_HpaI

0
100
200
300
340 a.a.

Protein Preferred Names

Protein Names

citramalyl-CoA lyase, mitochondrial

(3S)-malyl-CoA thioesterase

Related Diseases

Diseases

Alias

Tinea Profunda

Deep Seated Dermatophytosis	Granuloma Trichophyticum
Majocchi'S Granuloma

Tinea Barbae

Dermatophytosis Of Beard

Penicilliosis

Peroxisomal Biogenesis Disorder

Zellweger Spectrum Disorders	Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum
Disorders Of Peroxisome Biogenesis	Zellweger Spectrum
Zellweger Syndrome Spectrum	Peroxisomal Biogenesis Disorders
Pbd, Zss	Pbd-Zsd
Pbd-Zss	Pbd-Zellweger Spectrum Disorder
Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum	Peroxisome Biogenesis Disorder
Peroxisome Biogenesis Disorder Spectrum	Peroxisome Biogenesis Disorders
Zellweger Spectrum Disorder	Hyperpipecolic Acidaemia

Zellweger Syndrome

Cerebrohepatorenal Syndrome	Zellweger Leukodystrophy
Zs	Congenital Iron Overload
Chr	Zws
Severe Pbd-Zsd	Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02852	CLYBL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLYBL	VGNC	VGNC:60992
Mus musculus	CLYBL	MGD	MGI:1916884
Rattus norvegicus	CLYBL	RGD	RGD:1304615
Canis familiaris	CLYBL	VGNC	VGNC:39374
Macaca mulatta	CLYBL	VGNC	VGNC:71202
Bos taurus	CLYBL	VGNC	VGNC:27475

Name
Email *

	Sorry, but the email address you supplied was invalid.