PPM1E - protein phosphatase, Mg2+/Mn2+ dependent 1E Gene

Homo sapiens

Also known as POPX1; PP2CH; caMKN; CAMKPN; CaMKP-N

Gene ID: 22843 | Gene type: protein coding

About PPM1E

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:58,755,854-58,985,179 (from NCBI)

This gene has 1 transcript (splice variant), 207 orthologues and 16 paralogues. Biased expression in brain (RPKM 6.5), testis (RPKM 3.8) and 3 other tissues.

Summary

This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

PPM1E Products(1)

mRNA	Protein	Name
NM_014906.5	NP_055721.3	protein phosphatase 1E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11864573	GOA
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	20801214	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27793001	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	20801214	GOA
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	11864573	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	20801214	GOA
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	11864573	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	11864573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1E Protein Structure

PP2C

0
200
400
600
755 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1E

ca(2+)/calmodulin-dependent protein kinase phosphatase N

Related Diseases

Diseases

Alias

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Osteoblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10963	PPM1E Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PPM1E	VGNC	VGNC:33211
Rattus norvegicus	PPM1E	RGD	RGD:735028
Felis catus	PPM1E	VGNC	VGNC:99323
Macaca mulatta	PPM1E	VGNC	VGNC:76073
Canis familiaris	PPM1E	VGNC	VGNC:44865
Mus musculus	PPM1E	MGD	MGI:2444096

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