NEIL3 - nei like DNA glycosylase 3 Gene

Homo sapiens

Also known as FGP2; FPG2; NEI3; ZGRF3; hFPG2; hNEI3

Gene ID: 55247 | Gene type: protein coding

About NEIL3

Cytogenetic location: 4q34.3 Genomic coordinates (GRCh38): 4:177,309,874-177,371,268 (from NCBI)

This gene has 2 transcripts (splice variants), 185 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.9) and 13 other tissues.

Summary

NEIL3 belongs to a class of DNA glycosylases homologous to the Bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving Bases damaged by Reactive Oxygen Species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]

NEIL3 Products(1)

mRNA	Protein	Name
NM_018248.3	NP_060718.3	endonuclease 8-like 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	23755964	GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	19170771	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	19170771	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in base-excision repair	IDA IDA: Inferred from direct assay	23755964	GOA
involved in single strand break repair	IDA IDA: Inferred from direct assay	19170771	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12433996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEIL3 Protein Structure

H2TH

zf-RanBP

zf-GRF

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

endonuclease 8-like 3

DNA glycosylase FPG2

Related Diseases

Diseases

Alias

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09189	NEIL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NEIL3	VGNC	VGNC:31990
Mus musculus	NEIL3	MGD	MGI:2384588
Macaca mulatta	NEIL3	VGNC	VGNC:75248
Rattus norvegicus	NEIL3	RGD	RGD:1310562
Canis familiaris	NEIL3	VGNC	VGNC:43728
Felis catus	NEIL3	VGNC	VGNC:63768

Name
Email *

	Sorry, but the email address you supplied was invalid.