TP53INP2 - tumor protein p53 inducible nuclear protein 2 Gene

Homo sapiens

Also known as DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1

Gene ID: 58476 | Gene type: protein coding

About TP53INP2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,704,344-34,713,436 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues.

Summary

The protein encoded by this gene promotes Autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

TP53INP2 Products(4)

mRNA	Protein	Name
NM_001329429.2	NP_001316358.1	tumor protein p53-inducible nuclear protein 2
NM_001329430.2	NP_001316359.1	tumor protein p53-inducible nuclear protein 2
NM_001329431.2	NP_001316360.1	tumor protein p53-inducible nuclear protein 2
NM_021202.3	NP_067025.1	tumor protein p53-inducible nuclear protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19056683	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	19056683	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22470510	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	19056683	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22470510	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19056683	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53INP2 Protein Structure

DOR

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

tumor protein p53-inducible nuclear protein 2

diabetes and obesity-regulated

Related Diseases

Diseases

Alias

Branchiootorenal Syndrome 2

BOR2	Bor Syndrome 2
Branchiootorenal Dysplasia 2	Branchio-Oto-Renal Dysplasia 2
Branchio-Oto-Renal Syndrome Type 2	Branchiootorenal Syndrome, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14921	TP53INP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TP53INP2	MGD	MGI:1915978
Bos taurus	TP53INP2	VGNC	VGNC:36237
Macaca mulatta	TP53INP2	VGNC	VGNC:108068
Rattus norvegicus	TP53INP2	RGD	RGD:735085
Canis familiaris	TP53INP2	VGNC	VGNC:47726

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