HCN2 - hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 Gene

Homo sapiens

Also known as FEB2; BCNG2; EIG17; HAC-1; BCNG-2; GEFSP11

Gene ID: 610 | Gene type: protein coding

About HCN2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:589,881-617,159 (from NCBI)

This gene has 1 transcript (splice variant), 256 orthologues, 17 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 15.0), heart (RPKM 4.6) and 2 other tissues.

Summary

The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]

HCN2 Products(1)

mRNA	Protein	Name
NM_001194.4	NP_001185.3	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

HCN2 Protein Structure

Ion_trans_N

Ion_trans

cNMP_binding

0
200
400
600
800
889 a.a.

Protein Preferred Names

Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

brain cyclic nucleotide-gated channel 2

Related Diseases

Diseases

Alias

Epilepsy, Idiopathic Generalized 17

Febrile Seizures, Familial, 2	EIG17
Familial Febrile Seizures 2	FEB2
Epilepsy, Idiopathic Generalized, Susceptibility To, 17	Familial Febrile Convulsions 2
Convulsions, Familial Febrile, 2

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Retinitis Pigmentosa 25

RP25	Retinitis Pigmentosa-25
Retinitis Pigmentosa, Type 25

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18940	Cilobradine		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13422	Zatebradine hydrochloride	Antagonist	99.06%	Unkown
HY-13422A	Zatebradine	Antagonist	99.27%	Unkown
HY-160505	RO-275	Inhibitor	/	Unkown
HY-RS06047	HCN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HCN2	VGNC	VGNC:29777
Felis catus	HCN2	VGNC	VGNC:102610
Rattus norvegicus	HCN2	RGD	RGD:620689
Canis familiaris	HCN2	VGNC	VGNC:81268
Mus musculus	HCN2	MGD	MGI:1298210
Others	HCN2	NCBI

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