SLC5A3 - solute carrier family 5 member 3 Gene

Homo sapiens

Also known as BCW2; SMIT; SMIT1; SMIT2

Gene ID: 6526 | Gene type: protein coding

About SLC5A3

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:34,073,578-34,106,260 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 11 paralogues. Broad expression in kidney (RPKM 12.8), thyroid (RPKM 10.4) and 21 other tissues.

Summary

Enables Potassium Channel regulator activity and transmembrane transporter binding activity. Predicted to be involved in inositol metabolic process; monosaccharide transmembrane transport; and myo-inositol import across plasma membrane. Predicted to act upstream of or within several processes, including peripheral nervous system development; positive regulation of Reactive Oxygen Species biosynthetic process; and regulation of respiratory gaseous exchange. Located in plasma membrane. Part of perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SLC5A3 Products(1)

mRNA	Protein	Name
NM_006933.7	NP_008864.4	sodium/myo-inositol cotransporter

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables myo-inositol:sodium symporter activity	IDA IDA: Inferred from direct assay	24595108	GOA
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	28793216	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24595108	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	28793216	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25756525	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25756525	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC5A3 Protein Structure

SSF

0
200
400
600
718 a.a.

Protein Preferred Names

Protein Names

sodium/myo-inositol cotransporter

Na(+)/myo-inositol cotransporter

Related Diseases

Diseases

Alias

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13289	SLC5A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC5A3	MGD	MGI:1858226
Macaca mulatta	SLC5A3	VGNC	VGNC:77611
Rattus norvegicus	SLC5A3	RGD	RGD:621530

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