2. Gene
  3. DLK2 - delta like non-canonical Notch ligand 2 Gene

DLK2 - delta like non-canonical Notch ligand 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DLK-2; EGFL9

Gene ID: 65989 | Gene type: protein coding

About DLK2

This gene has 4 transcripts (splice variants), 201 orthologues and 8 paralogues. Broad expression in skin (RPKM 1.9), prostate (RPKM 1.6) and 23 other tissues.

Summary

Predicted to enable Notch binding activity. Involved in negative regulation of Notch signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

DLK2 Products(4)

mRNA Protein Name
NM_001286655.1 NP_001273584.1 protein delta homolog 2 isoform b precursor
NM_001286656.2 NP_001273585.1 protein delta homolog 2 isoform c precursor
NM_023932.4 NP_076421.2 protein delta homolog 2 isoform a precursor
NM_206539.2 NP_996262.1 protein delta homolog 2 isoform a precursor

DLK2 Protein Structure

hEGF

hEGF: Human growth factor-like EGF (45 - 57)

EGF

EGF: EGF-like domain (95 - 126)

hEGF

hEGF: Human growth factor-like EGF (159 - 171)

EGF

EGF: EGF-like domain (178 - 207)

EGF

EGF: EGF-like domain (216 - 246)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
Protein Preferred Names Protein Names

protein delta homolog 2

EGF-like protein 9

Related Diseases

Diseases Alias
Spinal Muscular Atrophy, X-Linked 2

SMAX2

Arthrogryposis Multiplex Congenita, Distal, X-Linked

Infantile-Onset X-Linked Spinal Muscular Atrophy

Xlsma

Amcx1

Spinal Muscular Atrophy, X-Linked Lethal Infantile

Spinal Muscular Atrophy, Infantile X-Linked

Amc, Distal, X-Linked

Spinal Muscular Atrophy, X-Linked 2, Infantile

X-Linked Spinal Muscular Atrophy 2

Spinal Muscular Atrophy With Arthrogryposis

X-Linked Distal Arthrogryposis Multiplex Congenita

X-Linked Spinal Muscular Atrophy Type 2

Xl-Sma

Arthrogryposis, X-Linked, Type I

Spinal Muscular Atrophy, X-Linked Infantile

X-Linked Infantile Spinal Muscular Atrophy

Arthrogryposis, X-Lined, Type I

Distal X-Linked Amc

Infantile X-Linked Sma

X-Linked Arthrogryposis Multiplex Congenita

X-Linked Arthrogryposis Type I

X-Linked Lethal Infantile Sma

Arthrogryposis Spinal Muscular Atrophy

Spinal Muscular Atrophy X-Linked 2

Amc Distal X-Linked

Arthrogryposis Multiplex Congenita Distal X-Linked

Arthrogryposis X-Linked Type I

Spinal Muscular Atrophy Infantile X-Linked

Spinal Muscular Atrophy X-Linked Lethal Infantile

Atrophy, Muscular, Spinal, X-Linked, Type 2, Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03807 DLK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DLK2 VGNC VGNC:39985
Bos taurus DLK2 VGNC VGNC:28093
Mus musculus DLK2 MGD MGI:2146838
Felis catus DLK2 VGNC VGNC:61518
Rattus norvegicus DLK2 RGD RGD:1309143
Others DLK2 NCBI