1. Gene
  2. QTRT1 - queuine tRNA-ribosyltransferase catalytic subunit 1 Gene

QTRT1 - queuine tRNA-ribosyltransferase catalytic subunit 1 Gene

Homo sapiens

Also known as TGT; TGUT; FP3235

Gene ID: 81890 | Gene type: protein coding

About QTRT1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,701,439-10,713,365 (from NCBI)

This gene has 12 transcripts (splice variants), 186 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 18.9), thyroid (RPKM 17.4) and 25 other tissues.

Summary

This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric Enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]

QTRT1 Products(1)

mRNA Protein Name
NM_031209.3 NP_112486.1 queuine tRNA-ribosyltransferase catalytic subunit 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20354154 GOA
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
20354154 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20354154 GOA
enables tRNA-guanosine(34) queuine transglycosylase activity IDA
IDA: Inferred from direct assay
20354154 GOA
Biological Process GO Annotation Evidence Reference Source
involved in tRNA-guanine transglycosylation IDA
IDA: Inferred from direct assay
20354154 GOA
Cellular Component GO Annotation Evidence Reference Source
part of tRNA-guanine transglycosylase complex IPI
IPI: Inferred from physical interaction
20354154 GOA
part of transferase complex IPI
IPI: Inferred from physical interaction
20354154 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

QTRT1 Protein Structure

TGT

TGT: Queuine tRNA-ribosyltransferase (141 - 377)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

queuine tRNA-ribosyltransferase catalytic subunit 1

TGT, 43-KD subunit

Related Diseases

Diseases Alias
Dyschromatosis Universalis Hereditaria

Duh

Atrophic Rhinitis

Rhinitis, Atrophic

Ozena

Rhinitis Sicca

Dry Rhinitis

Ozaena

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus QTRT1 RGD RGD:620996
Bos taurus QTRT1 VGNC VGNC:33607
Canis familiaris QTRT1 VGNC VGNC:45240
Mus musculus QTRT1 MGD MGI:1931441
Felis catus QTRT1 VGNC VGNC:64463