GALR3 - galanin receptor 3 Gene

Homo sapiens

Gene ID: 8484 | Gene type: protein coding

About GALR3

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,823,382-37,825,485 (from NCBI)

This gene has 1 transcript (splice variant), 97 orthologues and 16 paralogues. Low expression observed in reference dataset.

Summary

The neuropeptide Galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human Galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]

GALR3 Products(1)

mRNA	Protein	Name
NM_003614.2	NP_003605.1	galanin receptor type 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables galanin receptor activity	IDA IDA: Inferred from direct assay	9832121	GOA
enables peptide hormone binding	IDA IDA: Inferred from direct assay	24517231	GOA
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	9832121	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA IDA: Inferred from direct assay	9832121	GOA
involved in galanin-activated signaling pathway	IDA IDA: Inferred from direct assay	9832121	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24517231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GALR3 Protein Structure

7tm_1

0
100
200
300
368 a.a.

Protein Preferred Names

Protein Names

galanin receptor type 3

GAL3-R

Related Diseases

Diseases

Alias

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1135	M1145	Agonist	99.60%	Unkown
HY-P1135A	M1145 TFA	Agonist	/	Unkown
HY-RS05266	GALR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GALR3	RGD	RGD:2658
Bos taurus	GALR3	VGNC	VGNC:29241
Macaca mulatta	GALR3	VGNC	VGNC:107792
Canis familiaris	GALR3	VGNC	VGNC:41102
Mus musculus	GALR3	MGD	MGI:1329003

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