GSTO1 - glutathione S-transferase omega 1 Gene

Homo sapiens

Also known as P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21

Gene ID: 9446 | Gene type: protein coding

About GSTO1

Cytogenetic location: 10q25.1 Genomic coordinates (GRCh38): 10:104,254,173-104,267,455 (from NCBI)

This gene has 7 transcripts (splice variants), 254 orthologues and 14 paralogues. Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues.

Summary

The protein encoded by this gene is an omega class Glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

GSTO1 Products(3)

mRNA	Protein	Name
NM_001191002.2	NP_001177931.1	glutathione S-transferase omega-1 isoform 2
NM_001191003.2	NP_001177932.1	glutathione S-transferase omega-1 isoform 3
NM_004832.3	NP_004823.1	glutathione S-transferase omega-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutathione dehydrogenase (ascorbate) activity	IDA IDA: Inferred from direct assay	11511179	GOA
enables glutathione transferase activity	IDA IDA: Inferred from direct assay	11511179	GOA
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	11511179	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25277244	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-ascorbic acid metabolic process	IDA IDA: Inferred from direct assay	11511179	GOA
involved in cellular response to arsenic-containing substance	IDA IDA: Inferred from direct assay	11511179	GOA
involved in negative regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	11035031	GOA
involved in positive regulation of ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	11035031	GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	11035031	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	12928150	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11511179	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSTO1 Protein Structure

GST_N_3

GST_C

0
100
200
241 a.a.

Protein Preferred Names

Protein Names

glutathione S-transferase omega-1

MMA(V) reductase

GSTO1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82350	GSTO1 Antibody (YA2095)	WB, IHC-P, ICC/IF	Human, Rat

Related Diseases

Diseases

Alias

Night Blindness, Congenital Stationary, Type 1a

Congenital Stationary Night Blindness 1a	CSNB1A
Hemeralopia-Myopia	Myopia-Night Blindness
Night Blindness, Congenital Stationary , 1a, X-Linked	Congenital Stationary Night Blindness With Myopia
Csnb, Complete, X-Linked	Night Blindness, Congenital Stationary, With Myopia
Nbm1	Complete Csnb X-Linked
Congenital Stationary Night Blindness 1a X-Linked	Nbmi
Night Blindness, Congenital Stationary, 1a	Complete X-Linked Csnb
Nyctalopia	Xlcsnb
X-Linked Congenital Stationary Night Blindness	Blindness, Night, Stationary, Congenital, Type 1a
Night Blindness	X-Linked Csnb
Night Blindness, Congenital Stationary, Type 2a

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111530	GSTO1-IN-1	Inhibitor	99.47%	Unkown
HY-161876	GSTO1-IN-2	Inhibitor	/	Unkown
HY-RS05884	GSTO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GSTO1	VGNC	VGNC:62731
Canis familiaris	GSTO1	VGNC	VGNC:41536
Mus musculus	GSTO1	MGD	MGI:1342273
Rattus norvegicus	GSTO1	RGD	RGD:70952

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