GPR120 Agonist 4 

GPR120 Agonist 4 (example 1) is a GPR120 agonist，with the EC₅₀ values of 1 μM and 0.35 μM for β-arrestin A and Calcium A. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus^[1].

GPR120 Agonist 4 (example 1) (0.012-25 μM, 90 min) can activate GPR120 through recruitment of β-Arrestin in CHO-K1 GPR120 β-Arrestin cells^[1].
GPR120 Agonist 4 (0.012-25 μM, 90 min) promotes the release of Ca²⁺ in HEK293 with human GPR120 clone, which verifies the activation effect of GPR120 Agonist 4 on GPR120^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GPR120 Agonist 4 (example 1) (0.2/0.3/1/3/10 mg/kg, i.p., 15/30/45/60/90 min) dose-dependently promotes a decrease in glucose levels of the high fat diet mice model^[1].
GPR120 Agonist 4 (1/3/10 mg/kg, i.p., 15/30/45/60/90 min) inhibits the glucose level of starvation mouse model in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

459.79

C₂₁H₁₅ClF₅NO₃

1628641-89-3

O=C(CCC1=CC(F)=C(C(F)=C1)OCC2=C(C(F)(F)F)C=CN2C3=CC=C(C=C3)Cl)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. SUI, Zhihua, et al. Bicyclic pyrrole derivatives useful as agonists of gpr120. WO2015134038. 2014-03-07