Blogs (14)

Vatalanib (PTK787) is an Inhibitor of VEGFR2/KDR

Vatalanib is an inhibitor of VEGFR2/KDR. Vatalanib induces inhibition of the angiogenic response to VEGF and PDGF.
ENMD-1198, an Orally Active Tubulin-Binding Agent, Reduces HIF-1α and STAT3 Activity

ENMD-1198 is an orally active microtubule-targeting agent with antiproliferative and antiangiogenic activity.
APG-1387, a Bivalent SMAC Mimetic, Induces Proteasomal Degradation of IAPs

APG-1387 is a bivalent SMAC mimetic and an IAP antagonist. APG-1387 induces apoptosis with anti-cancer activity.
PU02 is an Allosteric Antagonist of 5-HT3 Receptor

PU02, a derivative of 6-MP, is an allosteric antagonist of 5-HT3 receptor. PU02 possesses anti-cancer cativity by inducing aopotosis.
RJW100 is a Potent LRH-1 and SF-1 Agonist

RJW100 is a potent LRH-1 and SF-1 agonist. RJW100 also causes strong activation of the miR-200c promoter and downregulates ZEB1 and ZEB2 proteins.
ZLDI-8, an ADAM-17 and Notch Inhibitor, Enhances Chemotherapeutic Effects

ZLDI-8 is an ADAM-17 inhibitor that makes tumor cells susceptible to anti-tumor agents and therefore overcoming the HCC multi-drug resistance process.
PI-103 is a Potent PI3K and mTOR Inhibitor

PI-103 is a potent PI3K and mTOR inhibitor, it also inhibits DNA-PK. PI-103 exhibits antiproliferative properties in a panel of human cancer cell lines.
CWP232228 is a Highly Potent and Selective Wnt/β-catenin Inhibitor

CWP232228, a highly potent selective Wnt/β-catenin signaling inhibitor, antagonizes binding of β-catenin to T-cell factor (TCF) in the nucleus.
AC-73 is a Specific and Orally Active CD147 Dimerization Inhibitor

AC-73 is a first specific, orally active the cluster of differentiation 147 (CD147) inhibitor and specifically disrupts CD147 dimerization.
CGS 15943 is an Orally Active Adenosine Receptor Antagonist

CGS 15943 is an orally bioavailable adenosine receptor antagonist with low nanomolar range Ki values for human A1, A2A, A2B, and A3 adenosine receptors.

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