2. Academic Validation
  3. Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells

Programmed Cell Death-1 Receptor (PD-1)-Mediated Regulation of Innate Lymphoid Cells

  • Int J Mol Sci. 2019 Jun 11;20(11):2836. doi: 10.3390/ijms20112836.
Grace Mallett 1,  Arian Laurence 2,  Shoba Amarnath 3
Affiliations

Affiliations

  • 1 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. g.mallett2@newcastle.ac.uk.
  • 2 Department of Haematology, University College London Hospitals NHS Trust, London NW1 2BU, UK. laurence.arian@icloud.com.
  • 3 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK. shoba.amarnath@newcastle.ac.uk.
PMID: 31212601 DOI: 10.3390/ijms20112836
Abstract

Programmed cell death-1 (PD-1) is a cell surface receptor that dampens adaptive immune responses. PD-1 is activated by the engagement of its ligands PDL-1 or PDL-2. This results in the inhibition of T cell proliferation, differentiation, cytokine secretion, and cytolytic function. Although a great deal is known about PD-1 mediated regulation of CD4+ and CD8+ T cells, its expression and function in innate lymphoid cells (ILCs) are yet to be fully deciphered. This review summarizes the role of PD-1 in (1) modulating ILC development, (2) ILC function, and (3) PD-1 signaling in ILC. Finally, we explore how PD-1 based immunotherapies may be beneficial in boosting ILC responses in Cancer, infections, and Other immune-related disorders.

Keywords

ILC; PD-1; PDL-1.

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