2. Academic Validation
  3. Two new glucoside derivatives of truxinic and cinnamic acids from Lavandula angustifolia mill

Two new glucoside derivatives of truxinic and cinnamic acids from Lavandula angustifolia mill

  • Nat Prod Res. 2021 Aug;35(15):2526-2534. doi: 10.1080/14786419.2019.1684283.
Gulnigar Ablikim 1 2,  Khayrulla Bobakulov 1 3,  Jun Li 1,  Nigary Yadikar 4,  H A Aisa 1
Affiliations

Affiliations

  • 1 The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China.
  • 2 University of Chinese Academy of Sciences, Beijing, P.R. China.
  • 3 Department of Physical Methods of Research, Acad. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
  • 4 College of Food Science and Pharmaceutical Science, Xinjiang Agricultural University, Urumqi, China.
PMID: 31674207 DOI: 10.1080/14786419.2019.1684283
Abstract

A phytochemical investigations on the n-butanol fraction of Lavandula angustifolia Mill. residues resulted in the isolation of ten compounds, including two new ones, 4,4'dimethoxy-2,2'di-O-β-d-glucopyranosyl-truxinate (1) and 2-(β-d-glucosyloxy)-trans-cinnamic acid butyl ester (2), along with eight known compounds. The structures of compounds were confirmed by NMR and HR-ESI-MS techniques and comparison with published data. The NMR data for 3 were attributed for the first time. Compound 2 was proofed to be a natural compound in plant rather than a butyl ester artifact formed by esterification reaction with butanol by comparative HPLC-DAD analysis with the ethanol extract which was obtained prior to the application of butanol. All isolated compounds were evaluated for their antioxidant and anti-hypoglycaemic activities. Among them, compounds 4 and 5 showed strong anti-oxidant activities against DPPH with IC50 values of 12.99 and 31.74 μM, respectively. Compound 5 exhibited moderate inhibitory activity against PTP1B with an IC50 value of 31.28 μM.

Keywords

Lavandula angustifolia Mill.; PTP1B; antioxidant activity; chemical constituents; cinnamic acid esters; structure elucidation; truxinic acid derivative.

Figures
Products