2. Academic Validation
  3. Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer

Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer

  • Curr Drug Res Rev. 2021;13(2):86-89. doi: 10.2174/2589977513666210127094222.
Ricardo David Couto 1,  Bruno Jose Dumêt Fernandes 2
Affiliations

Affiliations

  • 1 Clinical Biochemistry Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia/UFBA, Salvador, Bahia, Brazil.
  • 2 Clinical Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia/UFBA, Salvador, Bahia, Brazil.
PMID: 33504322 DOI: 10.2174/2589977513666210127094222
Abstract

Naltrexone (NTX) is an opioid antagonist that inhibits cell proliferation in vivo when administered in low doses. Naltrexone in low doses can reduce tumor growth by interfering with cell signalling as well as by modifying the immune system. It acts as an Opioid Growth Factor receptor (OGFr) antagonist and the OGF-OGFr axis is an inhibitory biological pathway present in human Cancer cells and tissues, being a target for the treatment with naltrexone low-dose (LDN). Clinical trials have proposed a unique mechanism(s) allowing LDN to affect tumors. LDN shows promising results for people with primary Cancer of the bladder, breast, liver, lung, lymph nodes, colon and rectum. This short review provides further evidence to support the role of LDN as an Anticancer agent.

Keywords

Low dose naltrexone; and treatment.; cancer; naltrexone; opioid growth factor receptor; tumor.

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