2. Academic Validation
  3. Lachnumon and lachnumol a, new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. I. Producing organism, fermentation, isolation and biological activities

Lachnumon and lachnumol a, new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. I. Producing organism, fermentation, isolation and biological activities

  • J Antibiot (Tokyo). 1993 Jun;46(6):961-7. doi: 10.7164/antibiotics.46.961.
M Stadler 1,  H Anke,  W R Arendholz,  F Hansske,  U Anders,  O Sterner,  K E Bergquist
Affiliations

Affiliation

  • 1 Universität Kaiserslautern, Lehrbereich Biotechnologie, Fed. Rep. Germany.
PMID: 8344878 DOI: 10.7164/antibiotics.46.961
Abstract

Several chlorinated metabolites with nematicidal, antimicrobial, and cytotoxic activities were isolated from submerged cultures of the ascomycete Lachnum papyraceum. Three compounds were identified as (+)-mycorrhizin A (3), (+)-chloromycorrhizin A (4) and (+)-dechloromycorrhizin A (5). The occurrence of 5 as a natural product is new. Two compounds, lachnumon (1) and lachnumol A (2), were found to be new Fungal metabolites with cytotoxic, nematicidal and antimicrobial activities.

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