MK-6884 

MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K_i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent^[1].

MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca²⁺ mobilization assay, with an EC₅₀ of 27 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[¹¹C]MK-6884 (compound 13) shows non-displaceable binding potential (BP_ND) of 0.83 in rhesus monkeys^[1].
[¹¹C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain^[1].
[¹¹C]MK-688 can penetrate the blood-brain barrier in monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

411.50

C₂₅H₂₅N₅O

2102194-04-5

Solid

Off-white to light yellow

N#CC1=NC(C2=CC3=C(CN(C)C3=O)C=C2)=C(C4=CN(CC5(C)CCCC5)N=C4)C=C1

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Tong L, et al. Discovery of [¹¹C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases. J Med Chem. 2020;63(5):2411-2425.  [Content Brief]