Phytic acid sodium salt  (Synonyms: myo-Inositol, hexakis(dihydrogen phosphate) sodium salt; Inositol hexaphosphate sodium salt)

Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound derived from the seeds of legumes. Phytic acid sodium salt is a [PO4]³- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research^{[1][2][3][4][5][6][7][8][9][10]}.

IC50: precursor for inositol phosphates and pyrophosphates^[1]

Phytic acid (0.05%-0.4% (wt/wt), 5 min) sodium salt and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains^[2].
Phytic acid (1-5 mM, 2-3 h) sodium salt decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells^[3].
Phytic acid (48-72 h) sodium salt provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells^[5].
Phytic acid (≥1 mM) sodium salt stimulates suicidal human erythrocyte death^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phytic acid (2%, diet, ad libitum for 21 d) sodium salt reduces growth performance of pigs partly through reduced capacity of the small intestine to absorb Na^[4].
Phytic acid (2%, drinking water, 6 months) sodium salt improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice^[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) sodium salt suppresses ischemia-induced hydroxyl radical generation in rat myocardium^[7].
Phytic acid (100 mg/kg/d, gavage, five days a week, 8 weeks) sodium salt shows protective effects against CCl₄-induced liver fibrosis in mice^[8].
Phytic acid (4% of rodent chow, diet, 30 days) sodium salt reduces lipogenic enzyme activities in diabetic rats^[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) sodium salt shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively^[10].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₆H₁₈O₂₄P₆.xNa

14306-25-3

Solid

White to off-white

O=P(O)(O)O[C@H]([C@H]([C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O)OP(O)(O)=O)[C@H]([C@H]1OP(O)(O)=O)OP(O)(O)=O.[x].[Na]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13(3):151-8.  [Content Brief]

  [2]. Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82(4):1040-1049.  [Content Brief]

  [3]. Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8.  [Content Brief]

  [4]. Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90(2):543-9.  [Content Brief]

  [5]. Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35.  [Content Brief]

  [6]. Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58(3):2028-33.  [Content Brief]

  [7]. Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4.  [Content Brief]

  [8]. Xu Z, et al. Protective effects of phytic acid on CCl4‐induced liver fibrosis in mice. Journal of Food Biochemistry, 2023, 2023(1): 6634450.

  [9]. Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494.  [Content Brief]

  [10]. Verghese M, et al. Anticarcinogenic effect of phytic acid (IP6): apoptosis as a possible mechanism of action. LWT-Food Science and Technology, 2006, 39(10): 1093-1098.