2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. PV1162

PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy.

For research use only. We do not sell to patients.

PV1162 Chemical Structure

PV1162 Chemical Structure

CAS No. : 1346559-65-6

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PV1162 Related Antibodies

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Chk1 Chk2

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Description

PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy[1].

IC50 & Target

Chk1

59000 nM (IC50)

Chk2

0.29 nM (IC50)

Molecular Weight

392.45

Formula

C21H24N6O2
CAS No.
SMILES

O=C(C(N1)=CC2=C1C=CC(OC)=C2)NC3=CC=C(/C(CCC)=N/NC(N)=N)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PV1162 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PV11621346559-65-6PV 1162PV-1162Checkpoint Kinase (Chk)Anti-cancerInhibitorinhibitorinhibit

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